Protein Info for CSW01_05635 in Vibrio cholerae E7946 ATCC 55056

Annotation: serine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00414: serine--tRNA ligase
  • amino acids 1 to 428 (428 residues), 572.5 bits, E=2.8e-176
• PF02403: Seryl_tRNA_N
  • amino acids 1 to 109 (109 residues), 101.2 bits, E=4e-33
• PF00587: tRNA-synt_2b
  • amino acids 230 to 411 (182 residues), 141.5 bits, E=3.1e-45

Best Hits

Swiss-Prot: 100% identical to SYS_VIBCH: Serine--tRNA ligase (serS) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01875, seryl-tRNA synthetase [EC: 6.1.1.11] (inferred from 100% identity to vcm:VCM66_1066)

MetaCyc: 71% identical to serine--tRNA ligase (Escherichia coli K-12 substr. MG1655)
Serine--tRNA ligase. [EC: 6.1.1.11]; 6.1.1.11 [EC: 6.1.1.11]

Predicted SEED Role

"Seryl-tRNA synthetase (EC 6.1.1.11)" in subsystem Glycine and Serine Utilization (EC 6.1.1.11)

MetaCyc Pathways

• superpathway of chorismate metabolism (51/59 steps found)
• tRNA charging (21/21 steps found)
• enterobactin biosynthesis (7/11 steps found)
• L-selenocysteine biosynthesis I (bacteria) (1/3 steps found)
• L-selenocysteine biosynthesis II (archaea and eukaryotes) (1/4 steps found)
• shinorine biosynthesis (3/8 steps found)
• vanchrobactin biosynthesis (3/8 steps found)
• colibactin biosynthesis (7/38 steps found)

KEGG Metabolic Maps

• Aminoacyl-tRNA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.11

Protein Sequence (435 amino acids)

>CSW01_05635 serine--tRNA ligase (Vibrio cholerae E7946 ATCC 55056)
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQ
LMASGDKAGAEAVKQQIGTLGDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDS
ENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKITGARFVVMKGQFARLHRAIAQ
FMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
TRPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYRE
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENYQEADGRIAI
PAVLQKYMGGLTHIG