Protein Info for CSW01_05430 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 693 signal peptide" amino acids 1 to 46 (46 residues), see Phobius details transmembrane" amino acids 513 to 532 (20 residues), see Phobius details PF00497: SBP_bac_3" amino acids 65 to 242 (178 residues), 69.7 bits, see alignment E=2.7e-23 amino acids 275 to 466 (192 residues), 88.9 bits, see alignment E=3.6e-29 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 532 to 677 (146 residues), 97.2 bits, see alignment E=4.3e-32 PF00990: GGDEF" amino acids 533 to 676 (144 residues), 102.9 bits, see alignment E=1.6e-33

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A0585)

Predicted SEED Role

"FOG: GGDEF domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (693 amino acids)

>CSW01_05430 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MGVFTIKCAAKNTTYHYSTSMLLNAFSRRVFLWLGWLLISTSSLAATSTTYKVATEADDV
VTRVLFDSIAHHFNLEIEYVNYPSFNDILVAIETGNADFAANITYTDLRAQRFDFSRPTN
IEYTYLYSYGGLRLPELRLVGIPKGTTYGTLLKEHYPYIQQVEYEGHLEALTLLESGRVD
GVVDAINQLKPMLLKGLDVQLLNDQLPIQPVSIVTPKGKHSALLGKIEKYAHSAHVQRLL
RESIQKYQLDIRKQALRQSVVESGLNVQRVLRVKLENNPQYALYQPDGSVRGISADVVFQ
ACEMLLLKCELVSNGQETWESMFDDLQDKSIDILAPITVSQQRKNLAYFSESYYHPQAIL
VKREHYKDDVYSNVSELVAERIGVIKDDFFEELLQQMLPNKILFSYASQEEKVQALLNKE
VDYIVLNRANFNLLLRESTEMLPIVEDTMIGSFYQYDIAIGFAKNPLGATLAPLFSRAIK
MLNTEQIIHTYDYQPNWRATLLAEKKYQRSTQWLFAMAFIVLFMVAFYLHGISHTDNLTK
LRNRRALYNRYRRGLSPRLSLVYLDVNTFKSINDQYGHEVGDKVLKQLAQRIEAVWRGRS
YRIGGDEFILIGECSAKRLEHVVAQCERFMFVDAERDVSFEVSVAIGIAKNRERTESLNE
VMHQADIAMYRAKAESTQSPFQAASKVKGLHIV