Protein Info for CSW01_05045 in Vibrio cholerae E7946 ATCC 55056

Annotation: dipeptide/tripeptide permease DtpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 514 transmembrane" amino acids 46 to 63 (18 residues), see Phobius details amino acids 70 to 91 (22 residues), see Phobius details amino acids 101 to 119 (19 residues), see Phobius details amino acids 126 to 145 (20 residues), see Phobius details amino acids 168 to 190 (23 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details amino acids 236 to 255 (20 residues), see Phobius details amino acids 261 to 277 (17 residues), see Phobius details amino acids 289 to 310 (22 residues), see Phobius details amino acids 339 to 357 (19 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 402 to 424 (23 residues), see Phobius details amino acids 434 to 456 (23 residues), see Phobius details amino acids 476 to 495 (20 residues), see Phobius details TIGR00924: amino acid/peptide transporter (Peptide:H+ symporter)" amino acids 27 to 501 (475 residues), 423.5 bits, see alignment E=6.4e-131 PF07690: MFS_1" amino acids 45 to 450 (406 residues), 46 bits, see alignment E=3.5e-16 PF00854: PTR2" amino acids 100 to 466 (367 residues), 282 bits, see alignment E=7.3e-88

Best Hits

Swiss-Prot: 59% identical to DTPA_CROTZ: Dipeptide and tripeptide permease A (dtpA) from Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)

KEGG orthology group: K03305, proton-dependent oligopeptide transporter, POT family (inferred from 100% identity to vco:VC0395_A0509)

MetaCyc: 58% identical to dipeptide/tripeptide:H+ symporter DtpA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-267; TRANS-RXN0-288

Predicted SEED Role

"Di/tripeptide permease DtpA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (514 amino acids)

>CSW01_05045 dipeptide/tripeptide permease DtpA (Vibrio cholerae E7946 ATCC 55056)
MTVGASQQTSTIALHNDTGMLMSNLNIFKQPNAFYLIFSIEFWERFGFYGMQAILTVYMV
KIMGMDESASFVLFGAFSALVYGFVAIGGWIGDKVIGTKRAITLGAIVMMVGYVLLGLST
ADHPLVGPTLIYIAMGFITVGNGLFKANPSSLLAKIYPENDPRLDGAFTMYYMAINLGSF
FSMIITPLVAIKMGYGMAFGVSAVGLAITVVNFLFCLRMLKGTGSPADLMPVNKMYLVLV
AVGSIIASLVCSYLLQNLTLAHGILVVAGLFILGCYFKEAFSMSGIERAKMLVAFILMLQ
GVVFFVLYFQMPTSLNFFAINNVEHHIFGFDVAPEQFQALNPFWIMIASPILAATYGKLG
DKLAMPFKFAFGMALCALSFLVLSWGTLFANEQGIISSNWLIASYAFQSIGELLVSGLGL
AMVAQLVPQRMMGFAMGMWFLTSASAAVIAGWVASLTSTPANVSGATESLHIYGEVFAQI
GYVTAGIAIVTFMIAPKLTRICRGESEPLELVTQ