Protein Info for CSW01_04695 in Vibrio cholerae E7946 ATCC 55056

Annotation: AcrB/AcrD/AcrF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1036 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 386 to 411 (26 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 485 (23 residues), see Phobius details amino acids 524 to 543 (20 residues), see Phobius details amino acids 852 to 870 (19 residues), see Phobius details amino acids 879 to 899 (21 residues), see Phobius details amino acids 905 to 929 (25 residues), see Phobius details amino acids 953 to 974 (22 residues), see Phobius details amino acids 980 to 1003 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1008 (1005 residues), 934.6 bits, see alignment E=6.9e-285 PF03176: MMPL" amino acids 336 to 485 (150 residues), 33.4 bits, see alignment E=2.5e-12 amino acids 801 to 1011 (211 residues), 37 bits, see alignment E=1.9e-13

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 100% identity to vch:VC0914)

MetaCyc: 100% identical to vibriobactin efflux pump RND permease (Vibrio cholerae O1 biovar El Tor str. N16961)
TRANS-RXN-502

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1036 amino acids)

>CSW01_04695 AcrB/AcrD/AcrF family protein (Vibrio cholerae E7946 ATCC 55056)
MWLSDVSVKRPVAALVLSMLLCVFGVVSFTKLAVREMPDIESPVVSVSTRYQGASATIIE
SQITSVLEDQLAGISGIDEITSVSRNGMSRITVTFELGYDLNTGVSDIRDAVARAQRSLP
EEADDPQVFKNNGSGQASVYINLSSSEMDRTQLTDYIERVLLDRFSLISGVSSVDVSGGL
YKVMYVRIKPELMAGRGVATSDISDALNKENLESPGGQVRNDSTVMSVRTARGYQSAEDF
EYLVVKRASDGTPIYLKDVADVFIGAENENSTFKSDGIVNVSMGIVPQSDANPLEVAKRV
HEEVDKVQQFLPKGTRLAIDYDSTVFIERSISEVYSTLFITGGLVILVLYIFIGQLRATL
IPAVTVPVSLISAFMAAYYFGFSINLITLMALILSIGLVVDDAIVVVENIFHHIERGEKP
LLAAYKGTREVGFAVIATTLVLVMVFLPISFMDGMVGLLFTEFSVLLAMAVIFSSLIALT
LTPVLGSKLLKANVKPGRFNQLIDRLFARLESGYRQVVSRAIRWRWAAPVVIAACIGGSY
GLMQLVPAQLTPSEDRGVIFSFVRGADATSYNRMAANMDLVEQRLMPLLGQGFLKSFSIQ
SPAFGGNAGDQTGFVIMILEDWNDRTVTAQEALSQVRKALAGIPDVRVFPFMPGFRGGSN
EPVQFVLGGSDYSELKTWAEKLEEEAEKSPFMTGADIDYSEKTPELVVTIDKQRAAELGI
SVKSISDTLEVMLGGKKVTTFVERGEEYDVYLRGDENSFNNAADLSQIYMRTATGELVTL
DTVTRIDEVASAIRLAHYNKQKSVTITANLEAGYTLGQALDFLDQKAQEILPNDISVSYS
GESKDFKENQSSVAIVFALALLVAYLVLAAQFESFINPLVVMLTVPMGVFGGFLGLFVMG
QGMNIYSQIGMIMLIGMVTKNGILIVEFANQLRDRGVEFEKAIIDASARRLRPILMTAFT
TLAGSIPLIVSTGAGYESRIAVGTVIFFGMGFATLVTLLVIPAMYRLISGSTQAPGHVEA
ELNHELQQDVKGRAQH