Protein Info for CSW01_04640 in Vibrio cholerae E7946 ATCC 55056

Annotation: methionine ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 225 transmembrane" amino acids 24 to 46 (23 residues), see Phobius details amino acids 64 to 84 (21 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 152 to 173 (22 residues), see Phobius details amino acids 194 to 216 (23 residues), see Phobius details PF00528: BPD_transp_1" amino acids 39 to 223 (185 residues), 88.7 bits, see alignment E=2.1e-29

Best Hits

Swiss-Prot: 100% identical to METI_VIBCH: Probable D-methionine transport system permease protein MetI (metI) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02072, D-methionine transport system permease protein (inferred from 100% identity to vch:VC0906)

MetaCyc: 54% identical to L-methionine/D-methionine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter permease protein" in subsystem Methionine Biosynthesis or Methionine Degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (225 amino acids)

>CSW01_04640 methionine ABC transporter permease (Vibrio cholerae E7946 ATCC 55056)
MSFNTIAQWFALNSDLLLTATWQTLYMVAIAGAVGFALGIPLGVILHTTKKEGLLENLPL
NRALGAVVNIGRSVPFLVLMVAIIPVTKLIVGTFIGTTAAIVPLTIGAIPFVARLIESAL
LEVPTGLVEAAQSMGATPLQIIRKVLLPEALPTILNSVTITLVTLVSYSAMAGTVGGGGL
GDVAIRYGFHRYDITIMAVTVVMLIVLVQIIQSIGDALVRRVDHR