Protein Info for CSW01_04635 in Vibrio cholerae E7946 ATCC 55056

Annotation: methionine ABC transporter substrate-binding protein MetQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 269 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details TIGR00363: lipoprotein, YaeC family" amino acids 15 to 269 (255 residues), 413.8 bits, see alignment E=1.5e-128 PF03180: Lipoprotein_9" amino acids 33 to 269 (237 residues), 325.5 bits, see alignment E=7.9e-102

Best Hits

Swiss-Prot: 100% identical to METQ_VIBCH: Probable D-methionine-binding lipoprotein MetQ (metQ) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02073, D-methionine transport system substrate-binding protein (inferred from 100% identity to vco:VC0395_A0427)

MetaCyc: 69% identical to L-methionine/D-methionine ABC transporter membrane anchored binding protein (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter substrate-binding protein" in subsystem Methionine Biosynthesis or Methionine Degradation or Staphylococcal pathogenicity islands SaPI

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (269 amino acids)

>CSW01_04635 methionine ABC transporter substrate-binding protein MetQ (Vibrio cholerae E7946 ATCC 55056)
MKFSLKSLLTIAAAASTLILAGCGEKAVDNNKVKIGVMAGAEAQVAEVAAKVAKEKYNLD
VELVTFTDYVTPNAALDDGSIDANAFQHKPYLDKQIADRGYKLAIVGNTFVYPIAGYSKQ
IKSVDELQDGARIAVPNDPTNLGRSLLLLQQQGLLKLREDVGLLATVRDIVENPKKLEIL
ELDAAQLPRSLDDVALSIINTTYASSINLTPEKDGIFVENKESPYVNILVAREANVNAEN
VQNFKKAYQTDEVAKAASEIFQGGAVKGW