Protein Info for CSW01_04140 in Vibrio cholerae E7946 ATCC 55056

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 313 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR03125: triphosphoribosyl-dephospho-CoA synthase CitG" amino acids 32 to 304 (273 residues), 386.2 bits, see alignment E=4.7e-120 PF01874: CitG" amino acids 34 to 303 (270 residues), 291.3 bits, see alignment E=4.9e-91

Best Hits

Swiss-Prot: 100% identical to CITG_VIBCH: Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (citG) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K05966, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 100% identity to vcm:VCM66_0759)

Predicted SEED Role

"2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC 2.7.8.25)" (EC 2.7.8.25)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (313 amino acids)

>CSW01_04140 triphosphoribosyl-dephospho-CoA synthase (Vibrio cholerae E7946 ATCC 55056)
MTIPAALDLLLELPSQASSSSGSRTFSLPRLVGHLAYHAMMLEVHLTPKPGLVDTANNGA
HRDMDLNTFIASAEAIAPYLHSFVSAGWESAGNPAAQLLSALRPIGIEAEQAMFAATQGV
NTHKGMIFILGLICGSVGWLKANQLKIDAQHIGETIRQACQFLVIDELKAKRDCEPETAG
ERIYRQYGLTGARGEAASGLAMVMQHALPAYQACLTKGASTEQALWHTLLVLMANNNDSN
LVSRGGLAGLHFVQEQAQQLLAKGGFLYQEIEQALTALDSVLIEKHLSPGGSADLLAATW
LIYELVQLFKVRH