Protein Info for CSW01_03705 in Vibrio cholerae E7946 ATCC 55056

Annotation: chaperone protein ClpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 857 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 6 to 853 (848 residues), 1444.5 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 68 (52 residues), 50.4 bits, see alignment 1.2e-16 amino acids 94 to 145 (52 residues), 48.6 bits, see alignment 4.3e-16 PF00004: AAA" amino acids 204 to 335 (132 residues), 50.7 bits, see alignment E=1.6e-16 amino acids 602 to 731 (130 residues), 38.8 bits, see alignment E=7.6e-13 PF17871: AAA_lid_9" amino acids 342 to 442 (101 residues), 121.1 bits, see alignment E=1.1e-38 PF07724: AAA_2" amino acids 596 to 759 (164 residues), 241.8 bits, see alignment E=2.3e-75 PF00158: Sigma54_activat" amino acids 600 to 729 (130 residues), 23.6 bits, see alignment E=2.3e-08 PF07728: AAA_5" amino acids 601 to 722 (122 residues), 50.8 bits, see alignment E=1.1e-16 PF10431: ClpB_D2-small" amino acids 766 to 844 (79 residues), 98.7 bits, see alignment E=9.5e-32

Best Hits

Swiss-Prot: 100% identical to CLPB_VIBCH: Chaperone protein ClpB (clpB) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 85% identity to vsa:VSAL_I0666)

MetaCyc: 76% identical to protein disaggregase ClpB (Escherichia coli K-12 substr. MG1655)
RXN185E-10

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (857 amino acids)

>CSW01_03705 chaperone protein ClpB (Vibrio cholerae E7946 ATCC 55056)
MRLDRFTSKFQIAISDAQSLALGRDHQYIEPVHLMVALLDQNGSPIRPLLTMLNVDVMQL
RSKLGEMLDRLPKVSGIGGDVQLSSALGSLFNLCDKVAQKRQDAYISSEIYLLAAIEDKG
PLGHLLKEFGLTEKKVSEAIEKIRGGQKVNDPNAEELRQALEKFTIDLTERAEQGKLDPV
IGRDDEIRRTIQVLQRRTKNNPVIIGEPGVGKTAIVEGLAQRIINNEVPEGLRGRRVLSL
DMGALVAGAKYRGEFEERLKSVLNELAKEEGNIILFIDELHTMVGAGKGEGSMDAGNMLK
PALARGELHCVGATTLDEYRQYIEKDPALERRFQKVLVDEPTVEDTIAILRGLKERYELH
HHVEITDPAIVAAASLSHRYISDRQLPDKAIDLIDEAASSIRMQIDSKPEALDKLERKII
QLKIEQQALSNEHDEASEKRLAILNEELQEKERDYAELEEVWKAEKAALSGTQHIKAALE
QARMDLEVARRAGDLNRMSELQYGRIPELEKQLDLAAQAEMQEMTLLRNKVTDAEIAEVL
SKQTGIPVSKMLEAEKEKLLRMEDVLHKRVIGQKEAVEVVANAIRRSRAGLSDPNRPIGS
FLFLGPTGVGKTELCKTLANFLFDSEDAMVRVDMSEFMEKHSVARLVGAPPGYVGYEEGG
YLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSSRIQENFARLDYQGIKEQVMDVVSKHFRPEFLNRVDESVVFHPLGQEHIKSIASIQLA
RLRQRLAERDYQLEVDDEALDLIAHVGFDPVYGARPLKRAIQQNVENPLAKSILAGKFLP
GSPILLSVKDGNIFASQ