Protein Info for CSW01_03305 in Vibrio cholerae E7946 ATCC 55056

Annotation: AcrB/AcrD/AcrF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1039 signal peptide" amino acids 12 to 12 (1 residues), see Phobius details transmembrane" amino acids 13 to 32 (20 residues), see Phobius details amino acids 338 to 355 (18 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 464 to 488 (25 residues), see Phobius details amino acids 533 to 551 (19 residues), see Phobius details amino acids 851 to 871 (21 residues), see Phobius details amino acids 879 to 900 (22 residues), see Phobius details amino acids 906 to 930 (25 residues), see Phobius details amino acids 955 to 972 (18 residues), see Phobius details amino acids 992 to 1020 (29 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1021 (1016 residues), 573 bits, see alignment E=1.1e-175 PF03176: MMPL" amino acids 847 to 1025 (179 residues), 20.6 bits, see alignment E=2e-08

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_003782)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1039 amino acids)

>CSW01_03305 AcrB/AcrD/AcrF family protein (Vibrio cholerae E7946 ATCC 55056)
MFTLIDAALSRTRTMLTLLVFILVAGVATYLTIPKESSPDVTIPIIYVSVSHQGISPSDA
ERLIVRPLEQEMRSIEGVKEMTATASEGHASVVLEFNVGVDLAKAMADVRDAVDLAKPKL
PADSDEPTVNEVTLAAEQPVLSVVLYGTVPERTTVLIARQLRDKLESFRQILSVDIAGDR
EEIVEIIVDPLLMESYGLDQSDIYNLIALNNRVVAAGFVDTGYGRFSVKVPSVFESLKDV
LELPIKVEGKQVITFGDVATVRKSFRDPESFARLDGKPAIVLDIKKRSGENIIETVELVK
AVLGEAQARDDWPNNLLVKTIWDESEDVKLMLNDLQNNILSAIILVVVVIIAILGVRTSL
LVGVSIPGSFLTGLLVLAVFGLTVNIVVLFALIMAVGMLVDGAIVVTEFADRRMQEGMHR
SEAYRDAAKRMAWPITASTATTLAAFAPLLFWPDVTGEFMKYLPLTLMATLTASLVMALL
FVPVLGSLFGRPQKVTQANQARMVALHNGDFSQATGITKAYYSTLAIAIRHPIKILCGAL
LMSAAIAFAYGKAGLGAEFFPEVDPPFFSVKVRSYGDLSLNEKDRIMSDIEQVMLGHDEF
ESVYTRTGGDDEIGVVQITPVDWQYRRSVKAIIEELEQVTDTFPGVEIEYKFPDAGPPVE
HDLEIEISARVADDLDKAAQQVRLWAEANPALTNLSDNGSKPGIDWKIDIRRDDASRFAA
DATLVGNTVQFVTNGLKIGDYLPDDSDEEVDILVRYPSEYRDIGRFDQLRVKTAQGLVPL
TNFAQIIPEQKQDTIHRVDGRRVISVMADLKEGYNLALELPAIEQALRELNLPSSVEFRI
RGQNEEQEHSAVFLEKAFMVALAAMAIILITQFNSFYQAFLILTAVIFSTVGVFAGLLIF
QKPFGIIMSGIGVIALAGIVVNNNIVLIDTYNQLLKRGLSREEAILRTGVQRLRPVLLTT
VTTILGLLPMVLEMNIDIINQKIEFGAPSTQWWSQLATAVAGGLAFATVLTLVLTPCLLM
LGRRRKGVSEDEAPQDAQS