Protein Info for CSW01_02585 in Vibrio cholerae E7946 ATCC 55056

Annotation: glutamine--fructose-6-phosphate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 610 (609 residues), 861.7 bits, E=1.4e-263
• PF13522: GATase_6
  • amino acids 63 to 175 (113 residues), 66.7 bits, E=3.2e-22
• PF13537: GATase_7
  • amino acids 86 to 182 (97 residues), 53.7 bits, E=3.1e-18
• PF01380: SIS
  • amino acids 289 to 419 (131 residues), 112.1 bits, E=2.6e-36
  • amino acids 463 to 592 (130 residues), 86.6 bits, E=1.9e-28

Best Hits

Swiss-Prot: 100% identical to GLMS_VIBCH: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 100% identity to vco:VC0395_A0039)

MetaCyc: 71% identical to L-glutamine--D-fructose-6-phosphate aminotransferase (Escherichia coli K-12 substr. MG1655)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• O-antigen building blocks biosynthesis (E. coli) (6/11 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (8/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (9/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (610 amino acids)

>CSW01_02585 glutamine--fructose-6-phosphate aminotransferase (Vibrio cholerae E7946 ATCC 55056)
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVE
AAQVAGGTGIAHTRWATHGEPSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFT
SQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTVVMDRNDPSRLVVARSGSPIV
IGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVA
CGTSYNAGMTARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
RLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLVTLLMLVTAL
GKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRA
RGGLLYVFADEVAGFEADETMKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQP
RNLAKAVTVE