Protein Info for CSW01_01500 in Vibrio cholerae E7946 ATCC 55056

Annotation: 50S ribosomal protein L11 methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 PF06325: PrmA" amino acids 2 to 293 (292 residues), 362.9 bits, see alignment E=6.4e-112 TIGR00406: ribosomal protein L11 methyltransferase" amino acids 3 to 287 (285 residues), 365.1 bits, see alignment E=1.4e-113 PF05175: MTS" amino acids 144 to 214 (71 residues), 37.5 bits, see alignment E=8.3e-13 PF01135: PCMT" amino acids 145 to 210 (66 residues), 20.3 bits, see alignment E=1.8e-07 PF13489: Methyltransf_23" amino acids 157 to 257 (101 residues), 30.1 bits, see alignment E=1.7e-10 PF02475: Met_10" amino acids 159 to 215 (57 residues), 26.1 bits, see alignment E=3e-09 PF13847: Methyltransf_31" amino acids 159 to 260 (102 residues), 41.2 bits, see alignment E=6.6e-14 PF13649: Methyltransf_25" amino acids 163 to 230 (68 residues), 32.8 bits, see alignment E=4.3e-11 PF08242: Methyltransf_12" amino acids 164 to 253 (90 residues), 31.1 bits, see alignment E=1.5e-10 PF08241: Methyltransf_11" amino acids 165 to 255 (91 residues), 26.6 bits, see alignment E=3.6e-09

Best Hits

Swiss-Prot: 100% identical to PRMA_VIBCH: Ribosomal protein L11 methyltransferase (prmA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02687, ribosomal protein L11 methyltransferase [EC: 2.1.1.-] (inferred from 99% identity to vco:VC0395_A2687)

MetaCyc: 72% identical to ribosomal protein L11 methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN0-5419

Predicted SEED Role

"Ribosomal protein L11 methyltransferase (EC 2.1.1.-)" in subsystem Heat shock dnaK gene cluster extended or Ribosome biogenesis bacterial (EC 2.1.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.-

Use Curated BLAST to search for 2.1.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (295 amino acids)

>CSW01_01500 50S ribosomal protein L11 methyltransferase (Vibrio cholerae E7946 ATCC 55056)
MPWIQIKLNATNDNAEAIGDMLMEETGAVSVTFLDAKDTPVFEPLPGETRLWGDTDVVAL
YEADMDTSLILQQIKASNMLAEGFAHKVEQVEDKDWEREWMDNFHPMQFGRRLWICPSWR
EVPDPQAVNVMLDPGLAFGTGTHPTTALCLEWLDNLDLSGKTVIDFGCGSGILAIAAIKL
GAAKVIGIDIDPQALLASKDNAARNGVEDQIEVYLPKDQPEGLVADVVVANILAGPLREL
SPIIKGLLKPGGQLAMSGILDTQAESVAEFYRDDLELDPIAEKSEWCRISGRKLG