Protein Info for CSW01_01380 in Vibrio cholerae E7946 ATCC 55056

Annotation: D-2-hydroxyacid dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02826: 2-Hacid_dh_C
  • amino acids 99 to 272 (174 residues), 143.9 bits, E=1.8e-46

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A2645)

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
• L-serine biosynthesis I (3/3 steps found)
• L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.95

Protein Sequence (307 amino acids)

>CSW01_01380 D-2-hydroxyacid dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MNNFHQLYILTEHDEHYREQILERQLEGLALTEDRAKATILLAAPPMAARRLDEFPRLQW
LHSAYAGVDTLMDPKLRKNYLLTNVKGIFGHLIAEYVMGYAIQYQRDFRLYQTQQAERLW
QPRPYSSLANQTLVILGTGSIGSHLAHVAKQFGLRVVGVNRTGIPAKEGHFDATYHISEL
PAALMRADLLVNTLPNTPATEGLLNQENLRHCHQALLFNVGRGKTLVEQGLPDLIAAGHI
RHAFLDVFIKEPLAQDHPFWDNPAITITPHIAAVSFPEQVVDIFADNYQRWCDNLPLRNQ
IDFEKGY