Protein Info for CSW01_01350 in Vibrio cholerae E7946 ATCC 55056
Annotation: polysaccharide biosynthesis protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to vcj:VCD_001361)MetaCyc: 56% identical to UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (Shigella sonnei)
RXN-13252 [EC: 4.2.1.135]
Predicted SEED Role
"UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)" in subsystem N-linked Glycosylation in Bacteria (EC 4.2.1.-)
MetaCyc Pathways
- UDP-N-acetyl-α-D-quinovosamine biosynthesis (2/2 steps found)
- UDP-2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactose biosynthesis (1/2 steps found)
- UDP-N-acetyl-α-D-fucosamine biosynthesis (1/2 steps found)
- UDP-N,N'-diacetylbacillosamine biosynthesis (1/3 steps found)
- UDP-yelosamine biosynthesis (1/3 steps found)
- superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (8/24 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Benzoate degradation via CoA ligation
- Benzoate degradation via hydroxylation
- Biosynthesis of type II polyketide backbone
- Biosynthesis of unsaturated fatty acids
- Butanoate metabolism
- Fatty acid biosynthesis
- Limonene and pinene degradation
- Nucleotide sugars metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Porphyrin and chlorophyll metabolism
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.-
Use Curated BLAST to search for 4.2.1.- or 4.2.1.135
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (621 amino acids)
>CSW01_01350 polysaccharide biosynthesis protein (Vibrio cholerae E7946 ATCC 55056) MFTPIQLLLSAQRHHKRMITLLYDVFALMFSLYAAIALRLDTLAFTFSFPEFLSMMTTVG VTLYCFVRLGMYRAVLRYMMLPAIGYIFLSVIISAVTLALSGFFFQAFIPRSVPFIYAGL ATLTLGGPRIFIRTIYYHYYKRQKPNVFIYGAGSTGRDLAYALIQGDEYHPVIFLDDDPA KTGQIIFGLRVHHSSDFESLRNLYEPVKMLIAINNIGKNTRIKLLERLSHWPIEIQSVPS VEDIAAGRAKATDVQDLDIADLLGRAPVEPDLALLQKNITEKSVMVTGAGGSIGSELCRQ ILAQKPKTLVLFELNEYNLYTIDQELQAIKQNLKLNTKIVAALGSVQRENRVKKLMQAHQ VETVYHAAAYKHVPLVEDNVIEGIRNNVFGTLACANAAIEAGVKNFTLISTDKAVRPTNI MGASKRMAELVLQALADKNSTTIFTMVRFGNVLGSSGSVVPLFKKQIRAGGPVTVTHPDI IRYFMLIPEAAQLVIQAGAMSHNGQVFVLDMGEPVKIVDLAKRMIHLMGMKEFCDGRSDE GDIEIKFTGLRPGEKLYEELLIGENVEGTSHQKIMTACEEKLSWDAMEDLLTELDVCCHN FDVECIKRILLDAPTGYSPQK