Protein Info for CSW01_00375 in Vibrio cholerae E7946 ATCC 55056

Annotation: Bcr/CflA family drug resistance efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 52 to 71 (20 residues), see Phobius details amino acids 78 to 97 (20 residues), see Phobius details amino acids 104 to 125 (22 residues), see Phobius details amino acids 137 to 159 (23 residues), see Phobius details amino acids 166 to 187 (22 residues), see Phobius details amino acids 208 to 233 (26 residues), see Phobius details amino acids 252 to 270 (19 residues), see Phobius details amino acids 280 to 299 (20 residues), see Phobius details amino acids 305 to 327 (23 residues), see Phobius details amino acids 339 to 361 (23 residues), see Phobius details amino acids 369 to 390 (22 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 10 to 378 (369 residues), 226.1 bits, see alignment E=4.8e-71 PF07690: MFS_1" amino acids 18 to 355 (338 residues), 161.6 bits, see alignment E=2.5e-51 PF00083: Sugar_tr" amino acids 55 to 193 (139 residues), 33.8 bits, see alignment E=1.8e-12

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 100% identity to vcj:VCD_001537)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (400 amino acids)

>CSW01_00375 Bcr/CflA family drug resistance efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MKQAMPSQVSKQQMVLLTLLVLFSPLAIDIYLPALPQISQAFHVEHALAQDTITWFLFAM
GVGQLFAGPLADKYGRRTVALGGISIYALSALLAWSAQSIEWMLMARLLQGLGACATSVA
AFATVRDLFGPQRSGKMISYLNGAICFIPALAPILGSWLTQQFGWRANFSFMTGFALLVG
LAMALRLQESNPYMGSRPAVFKLSRYAAVLKAPTFLFHASLCLLAMAVILAYVTSAPVIL
MERLQLSMNEFTFWFGVNAVINIIACMTAPKVMDKLGTRWSLIIGITTLMIAGSLMLVLR
NQASALAFMLPVFLSSIGFAWILGAAAGKALAPFGDKAGTAAALLGLFQMSGSGLLVGTL
QRIMPEPQLLIGLTMWLAAPALLILFSPLGFRWHASVSEC