Protein Info for CSW01_00245 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA-protecting protein DprA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR00732: DNA protecting protein DprA" amino acids 75 to 287 (213 residues), 258.5 bits, see alignment E=1.8e-81 PF02481: DNA_processg_A" amino acids 77 to 278 (202 residues), 264.8 bits, see alignment E=4e-83 PF17782: DprA_WH" amino acids 319 to 364 (46 residues), 42 bits, see alignment 7.8e-15

Best Hits

KEGG orthology group: K04096, DNA processing protein (inferred from 100% identity to vcm:VCM66_0048)

Predicted SEED Role

"Rossmann fold nucleotide-binding protein Smf possibly involved in DNA uptake" in subsystem Conserved gene cluster associated with Met-tRNA formyltransferase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (371 amino acids)

>CSW01_00245 DNA-protecting protein DprA (Vibrio cholerae E7946 ATCC 55056)
MKDQDLAAWLALCFTPKLGSKTISHLLATRLPAQLQSFTPKQWLACGLKPEQLVFLTTQA
AKQAEQCLQWRSAANNRYIVTPHCPLYPRLLKEINSSPPVLFIEGIWEAVHDPAVAIVGS
RNASVDGRQIARQFATELAQSGLVVTSGLALGIDGYAHDGALQAQGQTVAVLGSGLAQVY
PKQHQGLAERIIAQGALVSEFAPHTPPKADHFPRRNRIISGLSLGVVVVEAAEKSGSLIT
ARYAAEQGREVFVVPGSIFNAASQGSNQLIRQGACLVQSVQQIHQELKNALTWSLSEQVP
YQATLFSAVQSDEELPFPELLANVGIEATPIDILASRTQIPVQDIMMQLLELELLGHVVA
VPGGYIRKGRG