Protein Info for CSW01_00220 in Vibrio cholerae E7946 ATCC 55056

Annotation: Trk system potassium transporter TrkA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details PF13241: NAD_binding_7" amino acids 2 to 86 (85 residues), 22.1 bits, see alignment E=1.3e-07 amino acids 233 to 320 (88 residues), 22.5 bits, see alignment E=9.7e-08 PF03807: F420_oxidored" amino acids 2 to 50 (49 residues), 26.8 bits, see alignment 4.5e-09 PF02254: TrkA_N" amino acids 3 to 115 (113 residues), 99 bits, see alignment E=1.6e-31 amino acids 235 to 350 (116 residues), 91.3 bits, see alignment E=4e-29 PF02080: TrkA_C" amino acids 156 to 225 (70 residues), 44.4 bits, see alignment E=8.9e-15 amino acids 390 to 436 (47 residues), 32.6 bits, see alignment 4.2e-11

Best Hits

Swiss-Prot: 95% identical to TRKA_VIBAL: Trk system potassium uptake protein TrkA (trkA) from Vibrio alginolyticus

KEGG orthology group: K03499, trk system potassium uptake protein TrkA (inferred from 100% identity to vch:VC0043)

Predicted SEED Role

"Trk system potassium uptake protein TrkA" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Conserved gene cluster associated with Met-tRNA formyltransferase or Glutathione-regulated potassium-efflux system and associated functions or Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (458 amino acids)

>CSW01_00220 Trk system potassium transporter TrkA (Vibrio cholerae E7946 ATCC 55056)
MKIIILGAGQVGGTLAENLVGENNDITVVDKNADRLRDLQDKYDLRVVNGHASHPDVLRE
AGAQDADMLVAVTNTDETNMAACQVAFTLFNTPNRIARIRSPQYLAEKEALFQSGAVPVD
HLIAPEELVTSYIERLIQYPGALQVVSFAEEKVSLVAVKAYYGGPLVGNALSALRDHMPH
IDTRVAAIFRQGRPIRPQGTTIIEADDEVFFVAASNHIRSVMSELQRLEKPYRRIMIVGG
GNIGASLAKRLEQTYSVKLIEHNYQRAEQLSEQLENTIVFCGDAADQELLSEENIDQVDV
FIALTNEDETNIMSAMLAKRMGAKKAMVLIQRSGYVDLVQGGVIDVAISPQQATISALLT
HVRRADIVNVSSLRRGAAEAIEAIAHGDESTSKVVGRAVGDIKLPPGTTIGAIVRGEEVL
IAHDRTVIEQDDHVVMFLVDKKYVPDVETLFQPSPFFL