Protein Info for CCNA_03844 in Caulobacter crescentus NA1000

Annotation: ATP-dependent endopeptidase hsl ATP-binding subunit HslU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 430 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 5 to 430 (426 residues), 596.8 bits, see alignment E=1.4e-183 PF07728: AAA_5" amino acids 52 to 89 (38 residues), 27 bits, see alignment 1.4e-09 PF00004: AAA" amino acids 53 to 102 (50 residues), 30 bits, see alignment 2.2e-10 amino acids 196 to 319 (124 residues), 32 bits, see alignment E=5.4e-11 PF07724: AAA_2" amino acids 198 to 316 (119 residues), 87.2 bits, see alignment E=4.8e-28 PF10431: ClpB_D2-small" amino acids 322 to 392 (71 residues), 25.7 bits, see alignment E=3.3e-09

Best Hits

Swiss-Prot: 100% identical to HSLU_CAUVN: ATP-dependent protease ATPase subunit HslU (hslU) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 100% identity to ccr:CC_3728)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8GW06 at UniProt or InterPro

Protein Sequence (430 amino acids)

>CCNA_03844 ATP-dependent endopeptidase hsl ATP-binding subunit HslU (Caulobacter crescentus NA1000)
MTEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTG
VGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVK
AKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKEVELQLADTGGPSFDIPGQPG
AAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIV
FLDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVA
KPSDLLPELQGRLPIRVELKGLSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAI
DALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADRGGETVTIDAAYVQERVGALA
ANADLSRFIL