Protein Info for CCNA_03801 in Caulobacter crescentus NA1000

Annotation: prolyl endopeptidase family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 signal peptide" amino acids 1 to 69 (69 residues), see Phobius details PF02897: Peptidase_S9_N" amino acids 71 to 289 (219 residues), 78.9 bits, see alignment E=3.5e-26 PF00326: Peptidase_S9" amino acids 549 to 749 (201 residues), 135.8 bits, see alignment E=1.6e-43

Best Hits

KEGG orthology group: K01322, prolyl oligopeptidase [EC: 3.4.21.26] (inferred from 100% identity to ccs:CCNA_03801)

Predicted SEED Role

"prolyl oligopeptidase family protein" in subsystem Synechocystis experimental

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.26

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CCK4 at UniProt or InterPro

Protein Sequence (753 amino acids)

>CCNA_03801 prolyl endopeptidase family (Caulobacter crescentus NA1000)
MEKPRQVRGRGDAGHDRPRSGRFPVQDIRKVGWRATECSIPSPAMMTLRNGSAAALALVL
LASGSARAQETDPHLALEAVESPEALAWVKAENDKTLPLLSSDPRFAGLQAEALKILAAK
DRIAMPNFVGKTVFNFWQDATHVRGVWRRTSLESYKSADPQWETVIDLDALSAAEGKNWI
WKGADCRPKTHDRCLVNLSNGGKDAVTVREFDLTTKTFVDPAAGGFVLPESKQSIEWLDA
DTLILTRDWGPGTTTDSGYGMVVKTLKRGQALNDAVEIYRGQKGDVSVRPNVIRDAKGGR
VVLIEQATDFFNSLYFEWTPKGLAPLPLPKKGGIVGMLDGLLVVKTEEPWTFAGVAIPAG
SLALVSPERLRPGAEIVASNGCNPCAILSPGPRQSIAQATVTDNRVVAVVYDNVRGSLVS
LENRGERGVVKTNLPVIDNAAVTLGSHSDEGDLVFYTDEGFATPTQLKLADATGTTAQTI
KALPAQFDASKLEVEQKVATSKDGTKIPYFLIHPKGHKHDGKNPLLLHAYGGFNLSKLPV
YDPLIGKLWLERGGSYAVANIRGGGEFGPGWHQAALKANRQRAYDDYFAVAEDLIAKKIT
SPRHLGAYGRSNGGLLMGVAMTQRPDLWNAVIVESPLLDMIRYTQLPAGASWIGEYGDPA
IPAERAWIEAYSPYQKLKAGVKYPLAYITTSTKDDRVHPGHARKFAARLDDLKVDNLYFE
NTDGGHANGADPKANARRWALHYTHLSRQLMDH