Protein Info for CCNA_03745 in Caulobacter crescentus NA1000

Annotation: formyltetrahydrofolate deformylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 280 PF01842: ACT" amino acids 2 to 54 (53 residues), 37.7 bits, see alignment E=1.4e-13 TIGR00655: formyltetrahydrofolate deformylase" amino acids 2 to 278 (277 residues), 340.9 bits, see alignment E=3.5e-106 PF00551: Formyl_trans_N" amino acids 83 to 260 (178 residues), 116.8 bits, see alignment E=1e-37

Best Hits

Swiss-Prot: 51% identical to PURU_CORS1: Formyltetrahydrofolate deformylase (purU) from Corynebacterium sp. (strain P-1)

KEGG orthology group: K01433, formyltetrahydrofolate deformylase [EC: 3.5.1.10] (inferred from 100% identity to ccs:CCNA_03745)

Predicted SEED Role

"Formyltetrahydrofolate deformylase (EC 3.5.1.10)" in subsystem One-carbon metabolism by tetrahydropterines (EC 3.5.1.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CE68 at UniProt or InterPro

Protein Sequence (280 amino acids)

>CCNA_03745 formyltetrahydrofolate deformylase (Caulobacter crescentus NA1000)
MILTLSCPDQRGIVAKVSAFLFERGCNILDAQQFDDQETGQFFMRVVFDADGADREALRG
DFGALADGFKMKWTLRNRADRYRVLLLASKFDHCLADLVYRWRIGELPMDITGVVSNHPA
QTYAHVDLSGLDFHHLPVTKETKFEQEAELWKLIQETKTDIVVLARYMQVLSDGLSAKLQ
GRCINIHHSFLPGFKGAKPYHQAHARGVKLIGASAHYVTGDLDEGPIIEQDVERISHRDT
PEDLVRKGRDIERRVLARALRYRLEDRVLLNGRKTVVFTD