Protein Info for CCNA_03727 in Caulobacter crescentus NA1000

Annotation: small-conductance mechanosensitive channel mcsS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 transmembrane" amino acids 37 to 59 (23 residues), see Phobius details amino acids 80 to 102 (23 residues), see Phobius details amino acids 109 to 139 (31 residues), see Phobius details PF05552: MS_channel_1st_1" amino acids 26 to 70 (45 residues), 27.6 bits, see alignment 4.4e-10 PF21088: MS_channel_1st" amino acids 85 to 125 (41 residues), 34.2 bits, see alignment 4.1e-12 PF00924: MS_channel_2nd" amino acids 128 to 192 (65 residues), 65 bits, see alignment E=1.1e-21 PF21082: MS_channel_3rd" amino acids 201 to 269 (69 residues), 22.2 bits, see alignment E=3.2e-08

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_3612)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CDV2 at UniProt or InterPro

Protein Sequence (328 amino acids)

>CCNA_03727 small-conductance mechanosensitive channel mcsS (Caulobacter crescentus NA1000)
MTTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAAR
FMRRTLTRVHRSNPDPTLESFAASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAI
GLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKSLDLLFTEIATPDNVKVMIPN
SKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTD
LSEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGE
GEHHNLLALIKPRRSRKATAKPTGVEKK