Protein Info for CCNA_03613 in Caulobacter crescentus NA1000

Annotation: 3-hydroxybutyryl-CoA dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 transmembrane" amino acids 64 to 87 (24 residues), see Phobius details PF13452: FAS1_DH_region" amino acids 19 to 117 (99 residues), 47.5 bits, see alignment E=3e-16 PF01575: MaoC_dehydratas" amino acids 20 to 111 (92 residues), 80 bits, see alignment E=1.7e-26 PF03061: 4HBT" amino acids 86 to 119 (34 residues), 21.5 bits, see alignment 3.7e-08

Best Hits

Swiss-Prot: 49% identical to CROR_METEA: 3-hydroxybutyryl-CoA dehydratase (croR) from Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_03613)

Predicted SEED Role

"MaoC family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CC15 at UniProt or InterPro

Protein Sequence (150 amino acids)

>CCNA_03613 3-hydroxybutyryl-CoA dehydratase (Caulobacter crescentus NA1000)
MIGPHPTGGYILEELSVGMTAEKHVTVTEERIQRFAEASDDFNPVHVDEAFAAKTAYRGR
IAHGLLSASFGSAVVGTILPGAGAIYLGQTLTFHKPVRIGDVVTARATVASIDTESARVV
LRCAALVGDEVVMDGEATVRVPRRRRPAKA