Protein Info for CCNA_03611 in Caulobacter crescentus NA1000

Annotation: glutathione-regulated potassium-efflux system protein kefC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 599 transmembrane" amino acids 13 to 28 (16 residues), see Phobius details amino acids 35 to 57 (23 residues), see Phobius details amino acids 71 to 90 (20 residues), see Phobius details amino acids 102 to 124 (23 residues), see Phobius details amino acids 130 to 151 (22 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 197 to 218 (22 residues), see Phobius details amino acids 238 to 266 (29 residues), see Phobius details amino acids 285 to 304 (20 residues), see Phobius details amino acids 310 to 333 (24 residues), see Phobius details amino acids 339 to 358 (20 residues), see Phobius details amino acids 370 to 396 (27 residues), see Phobius details amino acids 553 to 569 (17 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 20 to 388 (369 residues), 190.1 bits, see alignment E=5.9e-60 PF02254: TrkA_N" amino acids 427 to 540 (114 residues), 78.3 bits, see alignment E=6e-26

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 100% identity to ccr:CC_3496)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CDT7 at UniProt or InterPro

Protein Sequence (599 amino acids)

>CCNA_03611 glutathione-regulated potassium-efflux system protein kefC (Caulobacter crescentus NA1000)
MAQEVSPESYKDLVLFLATAGIVAPIFKRLKINPILGYLLAGVILGPFGLGRFIPYAPWL
DYFTVDNPDEIAQLAEFGVVFLLFMIGLELSWERLRLMRRWVFGLGAVQVIGCSLALGAG
GMLLGLEPVVALTIGAALTLSSTAIAVPVLAERRRLHSEAGRATFSVLLFQDLAVAPILI
TLAILGRGNGSFQLQDLLALAPAALGLAVIVLVGRLALRPMLKSVAKAKSEEMFMAACLL
VIIGAGMVAALSGLSMALGAFVAGVLLAETEYRHEVEVKIEPFKGLLLSLFFVSLGIRLD
LSLLAAQPAAILGTALGLLVLKTAVVFGSGLLMGLNRRAAIEAALILAAGGEFAFVLLDN
AMSAQVVPPAIGQAVLVSATLTMFLIPGLAALGGYLGRKNAPLPVSEAPPSTANEPDRLG
PEPAGQVLVIGYGRVGRLVGDMLGRHDLPWIAVEREARLVEQGRRDGARIYYGDASRLEL
LERCGLATARAVVVTMDAFEVAEAVVVAARGARPDVPIVVRARDARHAARLYELGATDAV
PETIEASLQLSEAVLVDIGVPMGLVIASIHERRDEYRKKLNRPDALGGRRRRLRDATLR