Protein Info for CCNA_03386 in Caulobacter crescentus NA1000

Annotation: multimodular transpeptidase-transglycosylase PbpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 733 transmembrane" amino acids 84 to 109 (26 residues), see Phobius details PF17093: PBP_N" amino acids 1 to 138 (138 residues), 308.9 bits, see alignment E=5.8e-97 PF00912: Transgly" amino acids 140 to 314 (175 residues), 206.9 bits, see alignment E=2.5e-65 TIGR02074: penicillin-binding protein, 1A family" amino acids 152 to 672 (521 residues), 639.6 bits, see alignment E=2.3e-196 PF00905: Transpeptidase" amino acids 409 to 637 (229 residues), 113.1 bits, see alignment E=2.3e-36

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_03386)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CES2 at UniProt or InterPro

Protein Sequence (733 amino acids)

>CCNA_03386 multimodular transpeptidase-transglycosylase PbpC (Caulobacter crescentus NA1000)
MNDWTLPPYKFDDGKSPGEPPKPGPASASDGVSQDPWAPQGPDPFRLSSDAATPPPPPEP
PPEEPFRADLKHAAAKKKARKWGWVWGTLLVGFLLAVLSVAGGGAYVWFKYLKDTPALPS
REALFAVNRAPGIRFEDRNGQVIATRGPRYGQRITLGTVPNYVPMAFLAAEDRRFYQHGA
IDVQGIARAAWINWRAGKTRQGASTLTQQLAKGLFLTPDRVVKRKLQEMLLAYKLEQILT
KDEILELYLNRIYFGAGTYGIDGASQTYFGKPASQLTLSEAALLASLPKAPSRLALTRDM
ERALARSRLILANMRKEGWITPEQESRALDDTPRLSPMALQDEGDYGWVLDYATAEAVKI
AGQNAPDLVVRLTIDPLLQSEGAEVVRQTMATETTRSGASQAALLSLSADGAIRAMVGGT
DYSESPFNRAVQAKRQPGSTFKPFVYAAAVEKGVLPTDMRVDEPVKFGTWEPENYSGGYR
GPMTVEDALVTSINTVAVKLGQEVGGPAIGDLVRRFGITSLPPSPDLSVALGSYEVNLLQ
ITSGFQVFQQGGLRIEPYVIESITTQGGQQIFQHQPPQGERRVYDVAHASMMVKMMKKVV
TQGTAQRAAFGRPVAGKTGTSQNWRDAWFVGFTPDYVTGVWVGNDDEKPMNKVVGGDIPA
SIWRRFMMTAHQTLAVRDFEWLLPDPAPQSEPDPRNGFYETLSAEFSRAASELETTTPVA
PAPGQPPPDNLPY