Protein Info for CCNA_03240 in Caulobacter crescentus NA1000
Annotation: glutamine synthetase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01915, glutamine synthetase [EC: 6.3.1.2] (inferred from 100% identity to ccr:CC_3138)Predicted SEED Role
"glutamine synthetase family protein" in subsystem Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis
MetaCyc Pathways
- L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- ammonia assimilation cycle I (2/2 steps found)
- L-glutamine biosynthesis I (1/1 steps found)
- superpathway of ammonia assimilation (plants) (2/3 steps found)
- ammonia assimilation cycle II (1/2 steps found)
- L-glutamate and L-glutamine biosynthesis (4/7 steps found)
- L-aspartate degradation II (aerobic) (1/3 steps found)
- L-aspartate degradation III (anaerobic) (1/3 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.3.1.2
Use Curated BLAST to search for 6.3.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H3CCN7 at UniProt or InterPro
Protein Sequence (460 amino acids)
>CCNA_03240 glutamine synthetase (Caulobacter crescentus NA1000) MMSAVADIQECRDFLAAHPQVKFVEVFFTSMTGVPRGKRLRVHELEAIYEYGRFLPGSVL VVDTNGADCEDTGLVWEDGDADRRARPVPGTLTLAPWLGPDVAQVMLSLYELDGTPNDLD PRHVLQRVLDRYAADGLTPVAACELEYYLVDLQRGPNGELLPAKSLQTGLRPTGIQVYGL PELEAHAPFLRELWDVADTLGVPLEGAISEFAPAQVELTLKHKPDALRAADDAVLYKRAA KGVALRHGMEATFMAKPWSDRAGNGFHVHLSVNDAAGNNLCASEDIEGSDLLKHAIGGMK VLLGEGMAILAPNANSYRRFKANSYAPVAPTWGVNNRTVSLRVPAGPPKTRHVEHRVAGA DGNPYLVLAVLLASAHHGITNKIDPGPAVIGDGYAAAAKENIRLPNNWFAAVDLFEQSSV LRDYLGDRFVDMFVSVKRTEQARFFEVVTELDFDWYLRNA