Protein Info for CCNA_03183 in Caulobacter crescentus NA1000

Annotation: beta-lactamase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF00144: Beta-lactamase" amino acids 44 to 379 (336 residues), 232.8 bits, see alignment E=6.1e-73 PF11954: DUF3471" amino acids 429 to 534 (106 residues), 83.8 bits, see alignment E=1e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_3086)

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CE61 at UniProt or InterPro

Protein Sequence (536 amino acids)

>CCNA_03183 beta-lactamase family protein (Caulobacter crescentus NA1000)
MLTTTRRAALISGLATTGLAAFGNRAFAQETGAVGAAVDKFAQDVMAAFPDQPGLGITVV
ENGQITLAKGYGVKALGGQDRCDESTVFGIASNTKAMTAALLAMLVEEGRVEWDAPVTQY
LPDFAMKDPIVTKLLTVRDLLVHRSGLSLGAGDLMIWPAPTHTRAEIVAGLKHLPIGGQF
RGGYAYDNVLYVVAGAVIEAVTGQTWEQVIKARIFDPLGMSNTVSSPRLVDQSRRALPHA
RLGPPVRGLGPQKVLPFDASFDAAGPAGGVNSCPADIGKWMQVQLGRGVSADGKRLWSEA
QAREMWKPQTITSSSDGPSNENPARPSMQAYALGWYVQDHRGERLLWHTGGLAGFISYTG
LLPGRKSGIMIMTNAEENPVLRSLRFGGPDRLQGRSDFDWIASSKRVQAEADAQTIKDAA
AATTPKGGGAPPSLPLEAYAGVYRDPWYGTVTISVTGKGKKKGLYVSFDKTPLLRGKLGP
FDGETFITTFEDRTQEDAFFTFDIKDGKAVSALVKAVSPLADFSYDYHDLRLTKEG