Protein Info for CCNA_03130 in Caulobacter crescentus NA1000

Annotation: cell cycle response regulator CtrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 231 PF00072: Response_reg" amino acids 3 to 112 (110 residues), 94.3 bits, see alignment E=5.4e-31 PF00486: Trans_reg_C" amino acids 145 to 221 (77 residues), 72.8 bits, see alignment E=2e-24

Best Hits

Swiss-Prot: 100% identical to CTRA_CAUVC: Cell cycle transcriptional regulator CtrA (ctrA) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K13584, two-component system, cell cycle response regulator CtrA (inferred from 100% identity to ccr:CC_3035)

Predicted SEED Role

"Two-component cell cycle transcriptional regulator ctrA, winged helix family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8H358 at UniProt or InterPro

Protein Sequence (231 amino acids)

>CCNA_03130 cell cycle response regulator CtrA (Caulobacter crescentus NA1000)
MRVLLIEDDSATAQTIELMLKSEGFNVYTTDLGEEGVDLGKIYDYDLILLDLNLPDMSGI
DVLRTLRVAKINTPIMILSGSSEIDTKVKTFAGGADDYMTKPFHKDEMIARIHAVVRRSK
GHAQSVIKTGDIVVNLDAKTVEVNGNRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYG
GMDEPELKIIDVFICKLRKKLAASAHGKHHIETVWGRGYVLRDPNEQVNAA