Protein Info for CCNA_03013 in Caulobacter crescentus NA1000

Annotation: alkyl hydroperoxide reductase subunit F

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 TIGR03140: alkyl hydroperoxide reductase subunit F" amino acids 1 to 517 (517 residues), 791.5 bits, see alignment E=1.6e-242 PF13192: Thioredoxin_3" amino acids 124 to 193 (70 residues), 29.6 bits, see alignment E=2.1e-10 PF07992: Pyr_redox_2" amino acids 213 to 504 (292 residues), 173.6 bits, see alignment E=2.3e-54 PF13738: Pyr_redox_3" amino acids 258 to 487 (230 residues), 56.9 bits, see alignment E=7.4e-19 PF00070: Pyr_redox" amino acids 356 to 430 (75 residues), 50.8 bits, see alignment E=7e-17

Best Hits

Swiss-Prot: 72% identical to AHPF_PSEAE: Alkyl hydroperoxide reductase subunit F (ahpF) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03387, alkyl hydroperoxide reductase subunit F [EC: 1.6.4.-] (inferred from 100% identity to ccs:CCNA_03013)

MetaCyc: 62% identical to alkyl hydroperoxide reductase, AhpF component (Escherichia coli K-12 substr. MG1655)
RXN-8506 [EC: 1.5.1.37]; R4-RXN [EC: 1.5.1.37, 1.11.1.26]

Predicted SEED Role

"Alkyl hydroperoxide reductase protein F (EC 1.6.4.-)" in subsystem Thioredoxin-disulfide reductase (EC 1.6.4.-)

Isozymes

Compare fitness of predicted isozymes for: 1.6.4.-

Use Curated BLAST to search for 1.11.1.26 or 1.5.1.37 or 1.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAI8 at UniProt or InterPro

Protein Sequence (527 amino acids)

>CCNA_03013 alkyl hydroperoxide reductase subunit F (Caulobacter crescentus NA1000)
MLDAGLKAQLTTYLQNLRQPITLVASLDDSKGSVDMRALLDDVASTSDKVSVRFDGDDAR
KPSFAIERAANDAEVRFAGLPLGHEFTSLVLALLHVGGHPPRIDAEVIERIKALDGDYQF
ETYFSQSCQNCPDVVQALNTMSALNPRIRHVAIDGALFKAEVEARQVMAVPTILLNGQAF
GQGRMEIEQILAKLDTGAADRMAEKIRAKDAFEVLVVGGGPAGAAAAIYAARKGIRTGVA
AERFGGQVLDTMDIENFISVPHTEGPKLASALEQHVKDYEVDVMNLQKAVGLVPAKTPGG
LHEIKLENGANLKARTLILSTGARWRNVNVPGEAEYKNKGVAYCPHCDGPLFKGKRVAVI
GGGNSGVEAAIDLAGIVAHVTLIEFDSQLRADAVLQRKLASLPNVTIIKSAMTTEIHGDG
SKVNGLTYKDRTSDTAHRVDLEGVFVQIGLVPNTEWLKDSGVALSPRGEIEVDYRGETSI
PGVFAAGDATVTPYKQIIIAMGEGAKASLSAFDYLIRLPASEAAEAA