Protein Info for CCNA_02914 in Caulobacter crescentus NA1000

Annotation: zinc metalloprotease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 543 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF01523: PmbA_TldD_1st" amino acids 59 to 123 (65 residues), 50.7 bits, see alignment E=2.5e-17 PF19290: PmbA_TldD_2nd" amino acids 157 to 247 (91 residues), 29.6 bits, see alignment E=1.3e-10 PF19289: PmbA_TldD_3rd" amino acids 288 to 535 (248 residues), 93.5 bits, see alignment E=1.7e-30

Best Hits

KEGG orthology group: K03568, TldD protein (inferred from 100% identity to ccs:CCNA_02914)

Predicted SEED Role

"TldD family protein, Actinobacterial subgroup" in subsystem Putative TldE-TldD proteolytic complex

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAA6 at UniProt or InterPro

Protein Sequence (543 amino acids)

>CCNA_02914 zinc metalloprotease (Caulobacter crescentus NA1000)
MDRRQFLAACGIGAGGVLLPGFGQAIAAEQLIETMDVAVKKRLADAALTAAKAAGASYCD
VRVGRYLRQFILTREANVQGVTNTESSGVGVRVIANGAWGFAATNNMSPESVAQTARLAV
AIAKANSKNQTAPVQLAPTKGVGEVKWATPIRRNGMEVSLQEKVDLLMRVNGAALKAGAN
FVNSSLFLINEQKYFASSDGSFIDQDVHRVWAPFTVTAIDKASGKFRSREGLSAPMGMGY
EYLDPKAEDKVLSPNGIISYNKSYDMVEDAQAAAVQAREKLTAKSVKPGRYDLVLDPNHL
GLTIHESIGHPLELDRVLGYEANFAGTSFATLDKREQRFQYGNEIVNVFADKVQPGSLGA
VGFDDEGIKTKSWPLIQGGKLVDYQTTRDQAHILGKTESDGCSYADSWSTVQFQRMPNVS
LEPGKKPLSLADMIGNVENGIYILGRGSFSIDQQRYNAQFGGTLFYEIKDGKITQPLEDV
AYQMRTPEFWNACSAICDERDYRLFGSFFDGKGQPSQVSAVSHGSSTTRFDGINVINTAR
SLG