Protein Info for CCNA_02839 in Caulobacter crescentus NA1000

Annotation: glutamate-ammonia-ligase adenylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 958 PF03710: GlnE" amino acids 43 to 288 (246 residues), 242.8 bits, see alignment E=7.7e-76 amino acids 562 to 798 (237 residues), 239 bits, see alignment E=1.1e-74 PF08335: GlnD_UR_UTase" amino acids 321 to 426 (106 residues), 82.2 bits, see alignment E=7.5e-27 amino acids 828 to 900 (73 residues), 26.2 bits, see alignment 1.4e-09

Best Hits

Swiss-Prot: 100% identical to GLNE_CAUVC: Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (glnE) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00982, glutamate-ammonia-ligase adenylyltransferase [EC: 2.7.7.42] (inferred from 100% identity to ccr:CC_2753)

Predicted SEED Role

"Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42)" in subsystem Ammonia assimilation (EC 2.7.7.42)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CBN1 at UniProt or InterPro

Protein Sequence (958 amino acids)

>CCNA_02839 glutamate-ammonia-ligase adenylyltransferase (Caulobacter crescentus NA1000)
MSKLADRLAPCGPVLDPKAAERAYEAIAKRAGEAMGQVDAAWGSLAPVFAASPYLAGLAR
RDGKRLPRILGGDPGETLAAILAAAEAVAAEPDFETARRVLRELKADLHLLTAISDLGGV
WDLDQVTGALTRFADAVLHAALAQAVRQEVSRGALTHVGDGSAGPAPGLFCVAMGKHGAF
ELNYSSDIDFSIFYAPEKLPVAEGHEPQAVAVRIANHLGRILQERTGDGYVFRIDLRLRP
DPSSTPPAMPVDAAMDYYESVGQNWERAAHIKARIAAGDAAEGAAFLEGLQPFIWRRNLD
FAAIADIHSIKRQIHTYKVDDRLTAKGADLKLGRGGIREIEFFVQTQQLILGGRQPDLRS
PRTLDALQALAAAGHVTPEDAAWLTQAYKDLRALEHRAQMIADDQTHKLPESDVERKKVA
ALWGEGNLRVFDAAVGKMLKGVNLRYGRLFAGEEALSSRFGSLVFTGVEDDPETLATLKR
MGFSSPERVAATIRGWHHGHIAATRTERGRELFTRLAPRLLDAANATGAPDQAFNRFSDF
FSRLSSGVQIQSLFLAQPRLFELIVEVMAFAPRLAATMAKRPTALDALLDPTFFGPIETP
AIAPWDPEDFEGAMDAARRLFRDQSFRIGVRVMSGTADARDIGRAFAELADLIIGGLAPA
ALAEVERIGGAFPGQVAVVALGKAGSREMTAKSDLDLMTLYVADDPRSMSALKDWSAEVF
YARLTQRLTSALSAPTGEGTLYEVDLKLRPSGTKGPVAVSFAAFEHYYEREAETWELLAL
TRARVVWASSPDFKARAEGAIAAALRRPRAWKKTAADVIEMRQLMERERPGKGDWDLKLD
PGGLVDIEFAAQFLQLAHAAADGPLRQNTGEALAALREAGLADAGALSRLEAAWRLEQDL
SQLIKVALEDGADVEVEPKAFKALLAKAGGVTQFKSLKPKLAKAKAEARAAYEAVVKG