Protein Info for CCNA_02759 in Caulobacter crescentus NA1000

Annotation: methionine aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 18 to 263 (246 residues), 298.9 bits, E=1.4e-93
• PF00557: Peptidase_M24
  • amino acids 27 to 255 (229 residues), 176.3 bits, E=3.6e-56

Best Hits

Swiss-Prot: 60% identical to MAP1_RICPR: Methionine aminopeptidase (map) from Rickettsia prowazekii (strain Madrid E)

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 100% identity to ccs:CCNA_02759)

MetaCyc: 55% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (10/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.18

Sequence Analysis Tools

See A0A0H3C9X3 at UniProt or InterPro

Protein Sequence (276 amino acids)

>CCNA_02759 methionine aminopeptidase (Caulobacter crescentus NA1000)
MTLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLA
REFILDNGGLPACLYYRGYPKTVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHG
DTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLGDIGHAIQSYVEAQRCSVVRD
FCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRD
KSLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG