Protein Info for CCNA_02642 in Caulobacter crescentus NA1000

Annotation: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 TIGR01085: UDP-N-acetylmuramyl-tripeptide synthetase" amino acids 18 to 481 (464 residues), 435.7 bits, see alignment E=1.2e-134 PF01225: Mur_ligase" amino acids 19 to 91 (73 residues), 43.8 bits, see alignment E=4.2e-15 PF08245: Mur_ligase_M" amino acids 102 to 310 (209 residues), 149.3 bits, see alignment E=2.2e-47 PF02875: Mur_ligase_C" amino acids 332 to 417 (86 residues), 78.9 bits, see alignment E=4.3e-26

Best Hits

Swiss-Prot: 100% identical to MURE_CAUVC: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (murE) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01928, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [EC: 6.3.2.13] (inferred from 100% identity to ccs:CCNA_02642)

Predicted SEED Role

"UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13)" in subsystem Methicillin resistance in Staphylococci or Peptidoglycan Biosynthesis (EC 6.3.2.13)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAA4 at UniProt or InterPro

Protein Sequence (486 amino acids)

>CCNA_02642 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase (Caulobacter crescentus NA1000)
MTKRLSDLFNRPFATDPVIAGVTADSRKVTTGWLFAALPGTKVDGRDFAEGAVAKGAAAI
LAPEGGLEGLGVPVVRSEDARRAYALAAAAFWGKQPAMCVAVTGTNGKTSVAGFCRQIFT
KLGHKAASMGTLGVVVSQPGQPDQQLTPPGLTTPDAGDVAEMIARLADMGVTHLALEASS
HGVDQRRIDGVKLSAAGFTNFTQDHLDYHGSMEAYRAAKLRLFDTLTPAGAMAVLNADSE
AFPDFAAAAVTSGQSVFSVGEEGQGLRLLSRTPTPAGQDLVVEAEGVVHHLKLPLAGAFQ
ASNVLVAAGLCIAAGEDSAKVLKALETLEGAAGRLQRVGRGPKGGEAYVDYAHTPDGLQT
VLEALRPHTAGKLIAVFGAGGDRDRGKRPLMGAIGAKLADIAIVTDDNPRSEDPASIRAA
ILEAAPGAREIGDRRAAIRAAVALMSEGDVLVVAGKGHEQGQIVAGVVHPFDDVAETLQA
LEGVDA