Protein Info for CCNA_02612 in Caulobacter crescentus NA1000

Annotation: alanyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00344: alanine--tRNA ligase
  • amino acids 6 to 860 (855 residues), 936.1 bits, E=1.1e-285
• PF01411: tRNA-synt_2c
  • amino acids 6 to 555 (550 residues), 723.2 bits, E=3.2e-221
• PF07973: tRNA_SAD
  • amino acids 652 to 703 (52 residues), 55.1 bits, 9.4e-19
• PF02272: DHHA1
  • amino acids 739 to 877 (139 residues), 67.5 bits, E=2.6e-22

Best Hits

Swiss-Prot: 100% identical to SYA_CAUVC: Alanine--tRNA ligase (alaS) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01872, alanyl-tRNA synthetase [EC: 6.1.1.7] (inferred from 100% identity to ccr:CC_2529)

Predicted SEED Role

"Alanyl-tRNA synthetase (EC 6.1.1.7)" (EC 6.1.1.7)

MetaCyc Pathways

• tRNA charging (19/21 steps found)
• shinorine biosynthesis (3/8 steps found)
• vanchrobactin biosynthesis (2/8 steps found)
• superpathway of chorismate metabolism (38/59 steps found)
• ergotamine biosynthesis (4/12 steps found)
• enterobactin biosynthesis (3/11 steps found)
• (2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis (2/10 steps found)
• bacillibactin biosynthesis (2/12 steps found)
• superpathway of ergotamine biosynthesis (5/18 steps found)
• sulfazecin biosynthesis (1/16 steps found)
• phosalacine biosynthesis (3/25 steps found)
• phosphinothricin tripeptide biosynthesis (3/25 steps found)
• corallopyronin A biosynthesis (2/30 steps found)
• colibactin biosynthesis (6/38 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Aminoacyl-tRNA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.7

Sequence Analysis Tools

See A0A0H3C9J0 at UniProt or InterPro

Protein Sequence (880 amino acids)

>CCNA_02612 alanyl-tRNA synthetase (Caulobacter crescentus NA1000)
MPSLNEIRSTFLDYFGKADHAVTPSAPLVPQNDPTLLFVNAGMVPFKNVFTGAETPAHPR
AASSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEQAILHAWTLLTAEFKL
PKDKLLVTVYHTDDEAADLWKKIAGLGDDRIIRIPTSDNFWSMGDTGPCGPCSEIFFDHG
PHIAGGPPGSPDEDGDRFIEIWNLVFMQFEQLAGGERISLPKPSIDTGMGLERIAAVLQG
QHDNYDIDLFKALIAASVELTGVKAEGAQAPSHRVIADHLRSSSFLLADGVSPSNEGRGY
VLRRIMRRAMRHAYLLGASEPLMHRLAPTLVREMGQAYPELRRAEALIVETLRQEEERFR
TTLGRGMGLLDEATANLAAGGVLDGETAFKLYDTYGFPLDLTQDAVRAKGLTVDTDAFDA
AMQKQREMARANWAGSGQQGAAAAWFSIKEKAGATDFVGYETTETTGVVKAIVVDGAEVE
SASAGQTVEVLLDRTSFYAESGGQAGDTGVIEAHGRESRVLDTQKQAGELHVHRVELASD
LKVGDQVVASVDADRRNTTRSNHSAAHLVHAALHHVLGPHVAQKGQMVDGERMRFDFSHG
GPLTAEELDRIEAEVNEVIRQNVPAETKEMAPQEAIEAGAVALFGEKYGDSVRVLTLGKS
LADEAKAYSVELCGGTHVARTGDIALFKIVSEQGVAAGVRRIEALTGEAARRFLLDQAGV
AKALADQFKTPVAEVATRVDALIADRKRLEKELAEAKKQLALGGGGAASGPEDVNGTALI
ARVLDGVGGKELRGVAEEFKKQLASGVVALVGTSDGKAAVTVAVTADLTGKFSAADLAKA
AVIAMGGQGAGGKADFAQGGAPDDSKAEEGLAAVKALLAG