Protein Info for CCNA_02586 in Caulobacter crescentus NA1000

Annotation: phosphoribosylformylglycinamidine synthase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 739 PF18072: FGAR-AT_linker" amino acids 17 to 56 (40 residues), 53.5 bits, see alignment 4.3e-18 TIGR01736: phosphoribosylformylglycinamidine synthase II" amino acids 21 to 734 (714 residues), 931.5 bits, see alignment E=1.7e-284 PF00586: AIRS" amino acids 77 to 191 (115 residues), 101.6 bits, see alignment E=5.3e-33 amino acids 443 to 559 (117 residues), 84.9 bits, see alignment E=8.1e-28 PF02769: AIRS_C" amino acids 205 to 358 (154 residues), 135.6 bits, see alignment E=2.6e-43 amino acids 574 to 706 (133 residues), 73.5 bits, see alignment E=3.3e-24

Best Hits

Swiss-Prot: 100% identical to PURL_CAUVC: Phosphoribosylformylglycinamidine synthase subunit PurL (purL) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 100% identity to ccr:CC_2500)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA58 at UniProt or InterPro

Protein Sequence (739 amino acids)

>CCNA_02586 phosphoribosylformylglycinamidine synthase II (Caulobacter crescentus NA1000)
MSTSSTPSAKPMAEMAAEFGLKPAEYDVVLKRLGREPNLVELGVFSVMWSEHCSYKSSKN
QLKKFPIDGPRVICGPGENAGVIDIGDGDAIIFKMESHNHPSYIEPYQGAATGVGGIMRD
VFTMGARPIALLNALRFGDPSHPKTKRLVDGVVAGIAGYGNCVGVPTVAGETNFHKGYNG
NILVNAMCVGLAKADSIFYSAAPGPGLAVVYFGSKTGRDGIHGATMSSAEFSEDSEEKRP
TVQVGDPFAEKLLIEATLELMATGAVAAIQDMGAAGLTSSSVEMAGKGGVGIELNMDMVP
QRETGMSAYEMMLSESQERMLAVLKPGREQDGHAIFEKWGLDAAVIGYTTDTGRLVLKHH
GETVCDVPLAPLFDDAPLYDRPWVQPALQPRLDPAAVPAPTNWNEAVLKIIGCPDMASKR
WLWEQYDRHVMADTLEDSATGCDAGIVRIHGTGKAIAVTSDCTPRYVQADPYEGGKQAVA
EAWRNLTAAGALPIAITDNLNFGSPEKPETMGQIVRATDGMAEACRALDFPVVSGNVSLY
NETNGVAIPPTPTVGGVGLLEDYDLRTGFGNVAEGDTLVLVGETRGELGASIYLREILGR
EDGAPPPVDLALERKTGDFVRGLISSGLVAGVHDLSDGGLLVAAADVALASKIGVTLNAT
SQTHAHAYLLGEDQARYLIATPDPDAVLEAAKEAGVHANVAGVAGGEAFASDGLFSVSLD
ALRAAHEAWLPGYMSAPKA