Protein Info for CCNA_02567 in Caulobacter crescentus NA1000

Annotation: sensory transduction histidine kinase pleC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 842 transmembrane" amino acids 29 to 50 (22 residues), see Phobius details amino acids 284 to 303 (20 residues), see Phobius details PF00989: PAS" amino acids 321 to 434 (114 residues), 50.7 bits, see alignment E=4.4e-17 PF12860: PAS_7" amino acids 455 to 557 (103 residues), 48.2 bits, see alignment E=2.8e-16 PF00512: HisKA" amino acids 600 to 669 (70 residues), 70.9 bits, see alignment E=1.8e-23 PF02518: HATPase_c" amino acids 715 to 829 (115 residues), 97.7 bits, see alignment E=1.4e-31

Best Hits

Swiss-Prot: 100% identical to PLEC_CAUVC: Non-motile and phage-resistance protein (pleC) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K07716, two-component system, cell cycle sensor histidine kinase PleC [EC: 2.7.13.3] (inferred from 100% identity to ccr:CC_2482)

Predicted SEED Role

"Two-component sensor histidine kinase PleC" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CCG1 at UniProt or InterPro

Protein Sequence (842 amino acids)

>CCNA_02567 sensory transduction histidine kinase pleC (Caulobacter crescentus NA1000)
MGRHGGPAAAGPTAPSAVRAKAVNAPSQVFVRIAILAALLLLAVYTAFGVHRLQREAMAQ
PGGAPLAAKADLIAGRVDANLAAQRAGLSAAADLLKRDPGATMDAAETTLRAAGGEAAAV
AVVSEAGVVAVAGRDDGADWKAAALAAGASGRTNWVGSVGETGRLYVATTTSLDRARAFV
IASGDASRLVADPEKGESGALALPDGKLIAARGRGVQGAGALREAFALSIEDLGDGPAAV
RGQAADGALLDVAVRPVAQGALLAVAAAPTRSVANLDRQVMEGAFSLLVPLGVGIALALL
LMIQSRKAEVAHREFIDSERRFRLAVEAARCGIWEWDLNGDQVYLSDVTGAMFGWGGGGV
VSGQDLLERISIDHRERVRQALANAAMYGAFDVSFRVPASEQGARSLWIDARGQGFGKPG
SEGHARIIGVALDVTEERIAQARAQAAENRLRDAIESVSEAFVLWDRQGRLLMCNRNYRS
VFSLEPKILKPGAARAEVNRFAALAIKQDHPAPDGAKGVREAEMMDGRWIQISERRTAEG
GLVMTAADITAIKTQEEARRRNEEQLQNAVAGLERSQEQLAELARKYETEKVKAESANKA
KSEFLANMSHELRTPLNAINGFSEIMMNEMFGPLGDQRYKGYSQDIHSSGQHLLALINDI
LDMSKIEAGKMNLKFESMHLEDVAEDAVRLVRNRAEAAGLKLDIDFPQLPEIEADYRAVK
QVLLNLLSNAIKFTPRAGSVTVRAEVRRDPFGDLIKVSVTDTGIGIAKEDLARLAKPFEQ
VESQFSKTTQGTGLGLALTKSLITMHDGVLEMHSTPGEGTTVSFTLPVRHSDQKITRDFV
AA