Protein Info for CCNA_02540 in Caulobacter crescentus NA1000

Annotation: N-acyl-L-amino acid amidohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details TIGR01891: amidohydrolase" amino acids 41 to 417 (377 residues), 334.3 bits, see alignment E=4.9e-104 PF01546: Peptidase_M20" amino acids 98 to 424 (327 residues), 142.5 bits, see alignment E=1.8e-45 PF07687: M20_dimer" amino acids 225 to 319 (95 residues), 35.5 bits, see alignment E=8.3e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_02540)

Predicted SEED Role

"Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A" in subsystem p-Aminobenzoyl-Glutamate Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9C6 at UniProt or InterPro

Protein Sequence (432 amino acids)

>CCNA_02540 N-acyl-L-amino acid amidohydrolase (Caulobacter crescentus NA1000)
MIGRVSTLALVAGLAMGAPAMAAPSAAKVEAAAKAVQPKVVAWRRDIHENPELGNQEVRT
AALIAKELKALGIEVREGVGKTGVVGVLKGGKPGKVVALRADMDALPVEEKTGLPFASKV
KATWEGRTVPVMHACGHDTHVAMLLGAATVLAGMKQDIQGTVVFIFQPAEEGPPAGEEGG
AKLMIRDGALDNPKVDAVFGVHIGPGDPHELNYRPEGFYASSDRITITVKGRQTHGARPW
AGIDMASVAADIIQATNQIAARQVDVGVSPSVLTIATINMGFRQNIIPEDLKMEGTMRTF
SKERREDLIARMQKSVTAIGDRYGAKAEVAFTQPYPVTYNDPALSKWVKGTLEKASPGKV
DDNAALVTGAEDFSMYAEKVPGVFIQLGGRKADVPRETVPVNHSPYFDVDEAVFETGVKA
HAFMALDYLAKK