Protein Info for CCNA_02480 in Caulobacter crescentus NA1000
Annotation: NAD-dependent benzaldehyde dehydrogenase II
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 40% identical to PCHA_PSEPU: 4-hydroxybenzaldehyde dehydrogenase (NADP(+)) (pchA) from Pseudomonas putida
KEGG orthology group: K00141, benzaldehyde dehydrogenase (NAD) [EC: 1.2.1.28] (inferred from 100% identity to ccr:CC_2397)MetaCyc: 40% identical to 4-hydroxybenzaldehyde dehydrogenase (Pseudomonas putida NCIMB 9866)
HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN [EC: 1.2.1.96]; 1.2.1.96 [EC: 1.2.1.96]
Predicted SEED Role
"Putative benzaldehyde dehydrogenase oxidoreductase protein (EC 1.2.1.28)" in subsystem Phenylpropanoid compound degradation (EC 1.2.1.28)
MetaCyc Pathways
- toluene degradation III (aerobic) (via p-cresol) (8/11 steps found)
- 1,3-dimethylbenzene degradation to 3-methylbenzoate (2/3 steps found)
- 1,4-dimethylbenzene degradation to 4-methylbenzoate (2/3 steps found)
- 3-chlorotoluene degradation II (2/3 steps found)
- toluene degradation to benzoate (2/3 steps found)
- 4-methylphenol degradation to protocatechuate (2/4 steps found)
- D-phenylglycine degradation (1/3 steps found)
- benzoate biosynthesis III (CoA-dependent, non-β-oxidative) (2/5 steps found)
- benzoate biosynthesis II (CoA-independent, non-β-oxidative) (1/4 steps found)
- 4-hydroxymandelate degradation (2/6 steps found)
- salicin biosynthesis (2/6 steps found)
- mandelate degradation I (1/5 steps found)
- 2,4-xylenol degradation to protocatechuate (1/7 steps found)
- toluene degradation IV (aerobic) (via catechol) (4/13 steps found)
- mandelate degradation to acetyl-CoA (5/18 steps found)
- superpathway of aerobic toluene degradation (12/30 steps found)
- superpathway of aromatic compound degradation via 3-oxoadipate (12/35 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (8/42 steps found)
KEGG Metabolic Maps
- Benzoate degradation via hydroxylation
- Biosynthesis of phenylpropanoids
- Toluene and xylene degradation
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.28 or 1.2.1.96
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H3C9W2 at UniProt or InterPro
Protein Sequence (487 amino acids)
>CCNA_02480 NAD-dependent benzaldehyde dehydrogenase II (Caulobacter crescentus NA1000) MSEPLLSADAWTDRLFSDGWVKPSGGVIAVQEPATETVLTQVGRADRSDVARAAASAKAA QPAWAALTADARQAILLRAADLLVEHAPDLAPWIMRESGSVAAKAAVELEHAAGFVRQAG AMATEAAGLVLPSSPGKTSIARRVPLGVVAVISPFNFPLVLSIRAVAPALATGNAVVLKP DPRTPISGGFLIARVFEAAGLPAGLLHVLPGDAEAGDALCRDPNIAMVAFTGSTGAGRKV GEVAGAHLKKVALELGGKNPLIILDDADPDVAASNAAWGAWLHQGQVCMTAGRLLVQRGI HDAVVERLAAKAGHLPVGDPMRGDVALGPLISRGQLDRVHAIVSDTVADGARLVAGGTHK GLCYAPTVLTGVAPGMRAFEEEIFGPIAAVTVFDDLDEAARLANDGPYGLSAGIISGSVG RAMTLGAKLEVGHLHINDQTVDAGPHSPFGGMKASGNGTRISGPANLDEFTTWRWETVKA AATAYPF