Protein Info for CCNA_02471 in Caulobacter crescentus NA1000

Annotation: cobalt-zinc-cadmium resistance protein czcC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 421 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF02321: OEP" amino acids 34 to 212 (179 residues), 27.5 bits, see alignment E=1.3e-10 amino acids 245 to 408 (164 residues), 60.6 bits, see alignment E=9e-21

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_02471)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAK6 at UniProt or InterPro

Protein Sequence (421 amino acids)

>CCNA_02471 cobalt-zinc-cadmium resistance protein czcC (Caulobacter crescentus NA1000)
MSSFFQGRSRRPWLFATALALATPLSAFAAPLGLSDALSRAAKADPARPALASRIAAAEA
GVRQAAVRPNPVIGVEVEDLAGTGRYALIDRAQATLYYQQSQERGGKREARTSLARSDIA
QVRLRDDVRMLDLLHEVEIAWIEAIAAEAEARLAADRLALAERARSEVDRRVKVARDPLF
AGARAEAQVAEAAGALAEAKARAANTRRALAAFWSGGEIEIDPAPLEDLSAADQIAGPAS
PVDLALLEAQRGLAAAKVRVEQSKSVQDPTWRAGLRYLNDGGDVAAIVGGSIPLGRYDTN
RGAIDQARAAQTAADLDLIGAKATLERKIAAAQASLAQKAGEARRITAEIIPANARTVDL
VRDGFNRGGFSYLDVIEAQRALIDARQRRLAVLKSFQLDRAQLDRLTGAHASLIPAPESA
Q