Protein Info for CCNA_02352 in Caulobacter crescentus NA1000

Annotation: membrane-bound aldehyde dehydrogenase, large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details PF20256: MoCoBD_2" amino acids 24 to 175 (152 residues), 64.4 bits, see alignment E=1.3e-21 amino acids 577 to 674 (98 residues), 51.7 bits, see alignment E=9.9e-18 PF02738: MoCoBD_1" amino acids 313 to 539 (227 residues), 126.6 bits, see alignment E=9.4e-41

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 100% identity to ccs:CCNA_02352)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA84 at UniProt or InterPro

Protein Sequence (724 amino acids)

>CCNA_02352 membrane-bound aldehyde dehydrogenase, large subunit (Caulobacter crescentus NA1000)
MDGEILRDPTRRFVLQSGAAVGGGLLLSFTMSSEGQAAGDTKVNAYVRIASDGKVTIASK
VPEVGQGIKTALPMLIAEELDVDWSAVTVEQAIADTKIYGRQVAGGSMATTLEYDGLRRV
GATVRALLIAAAAARWNVPADSLKTEPGFVVDAAGKRRASYGELAQAAAALTPPDPKSLT
LKDPKAFRIIGKSHKSQNLDAIVTGQPTYGIDVRLPGMLFAAFAKAPVYGAKVASVDLAL
AKAVKGVRDAFIIEGGTNLQGLLPGVAVVADSWWAARKGREALQIQWAEHPTASQSTVGF
AAKAAELAAAPPHRNLHNDGDVEAALKGAAKTVSAAYSYPFIAHAALEPQNCTAHVKDGK
VEIWAPTQNPESGRALVARALNVDPSAITIHLIRGGGGFGRRLMNDYMVEAAAIAAKVNA
PVQLIWTREDDMQHDFYRPGGWHNLTAGLDAKGGLTAWKNHFITFGEGETFNTAAAMNAT
QFPCRAVANYRHDVSVMPLGFPTGFLRAPGNNAFGFVIQSFTDELALAAGKDPVAFRREL
LGEPRLLGEPGKGDSFHTGRMRGVLDLVAEMSGWGRKVPKGTGLGVACHYSHLGYVAVVM
QVTVKDGAVKVDKVWAAADVGRQIVNPSGADQQMQGSILDAIGSTLYQSITFENGAATNS
NFGDFPLLRMADAPPVEVRYKLSDNNPTGLGEPAYPPAPAALCNAIFAATGKRIRSLPIG
DQLA