Protein Info for CCNA_02347 in Caulobacter crescentus NA1000

Annotation: phosphomannomutase/phosphoglucomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 26 to 157 (132 residues), 101.2 bits, E=8.1e-33
• PF02879: PGM_PMM_II
  • amino acids 174 to 272 (99 residues), 90.3 bits, E=2.2e-29
• PF02880: PGM_PMM_III
  • amino acids 278 to 389 (112 residues), 56.2 bits, E=7.5e-19
• PF00408: PGM_PMM_IV
  • amino acids 414 to 482 (69 residues), 29.2 bits, E=1.6e-10

Best Hits

KEGG orthology group: K01835, phosphoglucomutase [EC: 5.4.2.2] (inferred from 100% identity to ccr:CC_2264)

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10) / Phosphomannomutase (EC 5.4.2.8)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis or Alginate metabolism or Mannose Metabolism (EC 5.4.2.10, EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• colanic acid building blocks biosynthesis (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• sucrose degradation IV (sucrose phosphorylase) (4/4 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• GDP-mannose biosynthesis (3/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
• glycogen degradation II (3/6 steps found)
• chitin biosynthesis (5/9 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• sucrose biosynthesis II (4/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (1/4 steps found)
• starch degradation III (1/4 steps found)
• starch degradation V (1/4 steps found)
• peptidoglycan recycling I (8/14 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen degradation I (3/8 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (1/8 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• starch biosynthesis (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.10, 5.4.2.2, 5.4.2.8

Use Curated BLAST to search for 5.4.2.10 or 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See A0A0H3CAF5 at UniProt or InterPro

Protein Sequence (498 amino acids)

>CCNA_02347 phosphomannomutase/phosphoglucomutase (Caulobacter crescentus NA1000)
MFSSPRADLVPNTAAYENEALVKATGFREYDARWLFGPEINLLGVQALGLGLGTYIHELG
QSKIVVGHDFRSYSTSIKNALILGLISAGCEVHDIGLALSPTAYFAQFDLDIPCVAMVTA
SHNENGWTGVKMGAQKPLTFGPDEMSRLKAIVLNAEFVERDGGKLIRVQGEAQRYIDDVA
KRASVTRPLKVIAACGNGTAGAFVVEALQKMGVAEVVPMDTDLDFTFPKYNPNPEDAEML
HAMADAVRETGADLAFGFDGDGDRCGVVDDEGEEIFADKIGLMLARDLAPLHPGATFVVD
VKSTGLYATDPILAQHGCKVIYWKTGHSYIKRKSAELGALAGFEKSGHFFMNGELGYGYD
CGLTAAAAILAMLDRNPGVKLSDMRKALPVAFTSLTMSPHCGDEVKYGVVADVVKEYEDL
FAAGGSILGRKITEVITVNGVRVHLEDGSWVLVRASSNKPEVVVVVESTQSEDDMRALFR
QEVKPRLGDRVGKYNQEI