Protein Info for CCNA_02261 in Caulobacter crescentus NA1000

Annotation: propionyl-CoA carboxylase biotin-containing subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00289: Biotin_carb_N
  • amino acids 1 to 110 (110 residues), 150.8 bits, E=8.7e-48
• PF02786: CPSase_L_D2
  • amino acids 115 to 321 (207 residues), 254.3 bits, E=3.9e-79
• PF02222: ATP-grasp
  • amino acids 138 to 292 (155 residues), 27.8 bits, E=8.2e-10
• PF07478: Dala_Dala_lig_C
  • amino acids 144 to 291 (148 residues), 34.6 bits, E=6.4e-12
• PF02785: Biotin_carb_C
  • amino acids 336 to 451 (116 residues), 109.3 bits, E=4.9e-35
• PF18140: PCC_BT
  • amino acids 471 to 594 (124 residues), 96.3 bits, E=7e-31
• PF00364: Biotin_lipoyl
  • amino acids 603 to 667 (65 residues), 58.8 bits, E=1.8e-19

Best Hits

KEGG orthology group: K01965, propionyl-CoA carboxylase alpha chain [EC: 6.4.1.3] (inferred from 100% identity to ccs:CCNA_02261)

Predicted SEED Role

"Biotin carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein" (EC 6.3.4.14)

MetaCyc Pathways

• methylaspartate cycle (15/19 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (12/17 steps found)
• 3-hydroxypropanoate cycle (9/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
• glyoxylate assimilation (8/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• mycolate biosynthesis (21/205 steps found)
• superpathway of mycolate biosynthesis (22/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14, 6.4.1.3

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.3

Sequence Analysis Tools

See A0A0H3CA85 at UniProt or InterPro

Protein Sequence (669 amino acids)

>CCNA_02261 propionyl-CoA carboxylase biotin-containing subunit (Caulobacter crescentus NA1000)
MFSKILIANRGEIAVRVIKTCRRLGIKTVVVYSDADAGSLAVEMADETVHIGASPANQSY
LVADKIIAACKQTGAQAVHPGFGFLSENAGFAQRCADEGIVFIGPNPGAISAMGDKIESK
KFAQAAGVSCVPGHIGEIADTAEAVKISEEIGYPVMIKASAGGGGKGIRVAWTRKDVEEG
FPAVRAEAKASFGDDRIFIEKFIESPRHIEIQVLGDKHGNVVHLFERECSIQRRNQKVIE
EAPSPLLDEATRNAMGAQAVALAKAVNYDSAGTVEFVAGQDKSFFFLEMNTRLQVEHPVT
ELITGLDLVEQMIRSAYGEKMAFGQSDLSINGWAIESRIYAEDPYRKFLPSIGRLVRYDP
PAEGDKDGPNGGYVVRNDAGVREGDEISMFYDPMISKLCTWAPTRLAAIDGMGRALEDFH
IEGLGQNIPFLAAVMDEERFRSGKLATSYIKDEFPDGFNGTTPTAVQLDILTAVGAAMQR
VYATRARSYESGLIGEARDEWVVAIGETRLRVKVGGEDGAVAVELLDEGRTLFLTDIDWR
PGKPVFKAVLNGLAFTVQAAPAAEGFTIRHRAAKTRVLVLTPRSAELHDKLPEKQAADTS
KLVLSPMPGLVVSMDVTTGQQVREGEVVCVLEAMKMQNIIRAERDGVVKAVNAKGGDPVA
ADEVLVEFA