Protein Info for CCNA_02254 in Caulobacter crescentus NA1000

Annotation: isovaleryl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 386 PF02771: Acyl-CoA_dh_N" amino acids 15 to 126 (112 residues), 133.6 bits, see alignment E=7.9e-43 PF02770: Acyl-CoA_dh_M" amino acids 130 to 223 (94 residues), 94.2 bits, see alignment E=9.2e-31 PF00441: Acyl-CoA_dh_1" amino acids 235 to 383 (149 residues), 154.4 bits, see alignment E=5.3e-49 PF08028: Acyl-CoA_dh_2" amino acids 251 to 366 (116 residues), 63.3 bits, see alignment E=5.9e-21

Best Hits

Swiss-Prot: 65% identical to IVD_SOLTU: Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) from Solanum tuberosum

KEGG orthology group: K00253, isovaleryl-CoA dehydrogenase [EC: 1.3.99.10] (inferred from 100% identity to ccs:CCNA_02254)

MetaCyc: 67% identical to isovaleryl-CoA dehydrogenase subunit (Pseudomonas aeruginosa PAO1)
RXN0-2301 [EC: 1.3.8.4]

Predicted SEED Role

"Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)" (EC 1.3.8.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.4 or 1.3.99.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9D3 at UniProt or InterPro

Protein Sequence (386 amino acids)

>CCNA_02254 isovaleryl-CoA dehydrogenase (Caulobacter crescentus NA1000)
MSMTFAPSMDFALGETADAIRETTARFAADKIAPIAAKIDETNSFPRELWVPMGDLGLHG
ITVEEEFGGLGLGYLEHVVAMEEVSRASASVGLSYGAHSNLCVNQIRRWATPEQKARYLP
KLISGEHVGSLAMSEAGAGSDVVSMKLRAEQVGDRYILNGTKFWITNAPHADTLVVYAKT
GEGSRGITAFIVEKGMKGFSVSKKLDKMGMRGSDTAELVFEDCEIPEENVMGPVGGGVGV
LMSGLDYERAVLAAGPLGIMQACLDVVLPYVRDRKQFGQPIGSFQLMQGKIADMYVALNS
ARAYVYAVAKACDAGKTTRFDAAGAILMASENAVKVSLEAIQALGGAGYTKEWPVERLLR
DAKLYDIGAGTNEIRRFLIGRELIGG