Protein Info for CCNA_02190 in Caulobacter crescentus NA1000

Annotation: penicillin-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 712 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 568 to 591 (24 residues), see Phobius details amino acids 611 to 631 (21 residues), see Phobius details amino acids 644 to 667 (24 residues), see Phobius details amino acids 687 to 708 (22 residues), see Phobius details PF00144: Beta-lactamase" amino acids 103 to 439 (337 residues), 220.7 bits, see alignment E=1.5e-69

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_02190)

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA22 at UniProt or InterPro

Protein Sequence (712 amino acids)

>CCNA_02190 penicillin-binding protein (Caulobacter crescentus NA1000)
MTSRASLAAAFAAAMLALCSAFGPEARAQDASSDAPPSAAAPPETTVRPYTSLRQRRARA
QRPAALTPTASRPAPVAAATPAPVSPPAPGVTPLPRPDLEAFVDGVVQRAMTRDHIAGVT
LSVVQNGQVVLKKGYGFSNLGQRKQVDPDKTLFRVASISKTFTWITLMNEIEAGRMRLDG
PVNLYLPEPLQVKDQGKKTQIRLRDLMTHTSGFEDRALGQLFERDPNRVRPLYDYLRQER
PRRVREPGLMPTYSNYGAALAGAAVSNVTGKPFEQLVSEEIIIPAGLTRTTFREARPWRD
DLPAPMAETLAADLSDAFSWTAMGWKTQPREFMGQVAPAASASSTASDMARYMTLLLNGG
TIDGKTIFSPRTAQAFRSPMYRPAPDAAGWNAGFQDVPLPGGRRGFGHQGATLYFHSNLV
IVPDLNLGIFVSVNTDSGANLPATLPATIVEHFYAPAQALPTASSLTYEQARLYEGDYLT
TRRAYGGLEGFTNRLIGRAQVRATPEGRLSVTDGGVTTLFNGTGRPGVFKAVEGPLTLVF
DSNGDRPSRFYAARGFSTFERIGFLHSAALLSWTVTIAGLACVITILGAMFRNRREARQT
PVQARAGQMQVMQAVLWLISGGCMAVFAAKATDQTTVFFGWPSGWLLSGSACALVAAALG
VLTLGLLPMVWRGGRRVDSWSDGRKVAFTFTALLLAFLSVLLALWGYLLPWS