Protein Info for CCNA_02134 in Caulobacter crescentus NA1000

Annotation: phosphogluconate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 TIGR01196: phosphogluconate dehydratase" amino acids 5 to 601 (597 residues), 971.2 bits, see alignment E=8.8e-297 PF00920: ILVD_EDD" amino acids 68 to 598 (531 residues), 533.8 bits, see alignment E=2.3e-164

Best Hits

Swiss-Prot: 60% identical to EDD_RHIME: Phosphogluconate dehydratase (edd) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 100% identity to ccs:CCNA_02134)

MetaCyc: 60% identical to phosphogluconate dehydratase (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydratase. [EC: 4.2.1.12]

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CB86 at UniProt or InterPro

Protein Sequence (602 amino acids)

>CCNA_02134 phosphogluconate dehydratase (Caulobacter crescentus NA1000)
MSLNPVIADVTARIVARSKDSRAAYLANMDRAIENQPGRAKLSCANWAHAFAASPGVDKL
RALDPNAPNIGIVSAYNDMLSAHQPLEAYPALIKDAARDVGATAQFAGGVPAMCDGVTQG
RPGMELSLFSRDVIAMATAVALTHDAFDSALYLGVCDKIVPGLVIGALTFSHLPALFVPA
GPMTSGLPNSEKARIRALYAEGKVGREELLAAESASYHGPGTCTFYGTANTNQMLMELMG
FHLPGSAFVHPNTPLREALVKESARRVAAVTNKGNEFIPVGRMIDEKSFVNGVVGLMATG
GSTNLALHIIAMAAAAGVQLTLEDLDDISKATPLLARVYPNGSADVNHFQAAGGMAFVIR
ELLKAGLVHEDVQTIAGAGLSLYAKEPVLEDGMLTWRDGAHESLDPAIVRPVSDPFSKEG
GLRLMAGNLGRGVMKISAVKPEHHVIEAPCAVFQEQEDFIAAFKRGELDRDVVVVVRFQG
PSANGMPELHNLSPSISVLLDRGHKVALVTDGRMSGASGKTPAAIHVTPEAAKGGPLAYV
QDGDVIRVNAETGELKIMVDEATLLARTPANVPASKPGFGRELFGWMRSGVGAADAGASV
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