Protein Info for CCNA_02037 in Caulobacter crescentus NA1000

Annotation: ATP-dependent endopeptidase Lon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 675 to 692 (18 residues), see Phobius details PF02190: LON_substr_bdg" amino acids 6 to 197 (192 residues), 196 bits, see alignment E=2.1e-61 TIGR00763: endopeptidase La" amino acids 8 to 766 (759 residues), 982.8 bits, see alignment E=8.1e-300 PF00004: AAA" amino acids 348 to 484 (137 residues), 82.9 bits, see alignment E=8.5e-27 PF07728: AAA_5" amino acids 348 to 481 (134 residues), 39 bits, see alignment E=2.4e-13 PF05362: Lon_C" amino acids 565 to 767 (203 residues), 324.5 bits, see alignment E=7.6e-101 PF13541: ChlI" amino acids 614 to 735 (122 residues), 34.3 bits, see alignment E=6e-12

Best Hits

Swiss-Prot: 100% identical to LON_CAUVC: Lon protease (lon) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 100% identity to ccs:CCNA_02037)

MetaCyc: 64% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8GX12 at UniProt or InterPro

Protein Sequence (799 amino acids)

>CCNA_02037 ATP-dependent endopeptidase Lon (Caulobacter crescentus NA1000)
MSELRTLPVLPLRDIVVFPHMVVPLFVGRDKSVRALEEVMRGDKQILLVTQKNSADDDPA
PGDIFEVGVLATVLQLLKLPDGTVKVLVEGKARAAVVSFTDQESYYEAQIGEVSEDDGAG
PEAEALSRAVVEQFENYVKLNKKVPPEALASIPQIAEPGKLADSIAAHLSVKIGDKQNLL
EIFDVVKRLEKVFALMEGEISVLQVEKKIRSRVKRQMEKTQREYYLNEQMKAIQRELGDP
DDARDELIDLEKRIKKTKLSKEARTKAESELKKLRNMSPMSAESTVVRNYLDWLLSIPWG
KAKTKKIDLVESEGILDADHYGLEKVKERILEYLAVQARTNSLKGPILCLVGPPGVGKTS
LGKSIAKATGREFVRMSLGGVRDEAEIRGHRRTYIGSMPGKVVQSMKKAKTTNAFVLLDE
IDKMGSDYRGDPASALLEVLDPSQNSTFGDHYLEVDYDLSQVMFVTTANSLNMPQPLLDR
MEIIRIPGYTEDEKLEIAKRHILPKLAKDHGLKPAEFIVPDKAIRDLIRYYTREAGVRSL
ERELGALARKTVRDLAREKVASITIDDERLAKYAGVKKYRYGETDEVDQVGIVTGLAWTE
FGGDILTIEAVKMPGKGRMQITGNLKDVMKESIAAANSYVRSRALQFGIKPPVFEKTDVH
IHVPDGATPKDGPSAGIAMALAMVSVLTGIPIRKDIAMTGEITLRGRVTAIGGLKEKLLA
ALRSGVKTVLIPQENEKDLADVPQTVKDGLEIIPVSTVDEVLKHALTGPLTPVEWNEAEE
PITTSAKKDDGDSDAMLTH