Protein Info for CCNA_01954 in Caulobacter crescentus NA1000

Annotation: ribonuclease E

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 898 TIGR00757: ribonuclease, Rne/Rng family" amino acids 14 to 480 (467 residues), 505.7 bits, see alignment E=5.2e-156 PF10150: RNase_E_G" amino acids 178 to 448 (271 residues), 329.8 bits, see alignment E=1.4e-102 PF20833: RNase_E_G_Thio" amino acids 460 to 543 (84 residues), 78.8 bits, see alignment E=2.8e-26

Best Hits

KEGG orthology group: K08300, ribonuclease E [EC: 3.1.26.12] (inferred from 100% identity to ccr:CC_1877)

Predicted SEED Role

"Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-)" in subsystem Bacterial Cell Division or RNA processing and degradation, bacterial (EC 3.1.4.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.26.12

Use Curated BLAST to search for 3.1.26.12 or 3.1.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAR6 at UniProt or InterPro

Protein Sequence (898 amino acids)

>CCNA_01954 ribonuclease E (Caulobacter crescentus NA1000)
MSKKMLIDAAHAEETRVVVVDGTRVEEFDFESQTRKQLRGNIYLAKVTRVEPSLQAAFIE
YGGNRHGFLAFNEIHPDYYQIPVADREALMRDDSGDDEDDTPISRRASGGDDEDDVNGGD
RAVDDDDDDVEEELARRKRRLMRKYKIQEVIRRRQIMLVQVVKEERGNKGAALTTYLSLA
GRYGVLMPNTARGGGISRKITAVTDRKRLKSVVQSLDVPQGMGLIVRTAGAKRTKAEIKR
DYEYLLRLWENIRENTLHSIAPALIYEEEDLVKRAIRDMYDKDLDGIWVEGDAGYKEARD
FMRMLMPSQAKKVFNYRDPTPLFVKNKIEDHLAQIYSPVVPLRSGGYLVINQTEALVAID
VNSGKATRERNIEATALKTNCEAAEEAARQLRLRDLAGLIVIDFIDMDEAKNNRTVEKVL
KDALKDDRARIQMGKISGFGLMEISRQRRRTGVLEGTTHVCEHCEGTGRVRSVESSALAA
LRAVEAEALKGSGSVILKVSRSVGLYILNEKRDYLQRLLTTHGLFVSVVVDDSLHAGDQE
IERTELGERIAVAPPPFVEEDDDFDPNAYDDEEEEDDVILDDEDDTDREDTDDDDATTRK
SARDDERGDRKGRRGRRDRNRGRGRRDERDGETESEDEDVVAEGADEDRGEFGDDDEGGR
RRRRRGRRGGRRGGREDGDRPTDAFVWIRPRVPFGENVFTWHDPAALVGGGESRRQAPEP
RVDAATEAAPRPERAEREERPGRERGRRGRDRGRRQRDEAPVAEMTSVESATVEAAEPFE
APILAPPVIAGPPADVWVELPEVEEAPKKPKRSRARGKKATETSVEAIDTVTEVAAEAPA
PETAEPEAVEVAPPAPTVEAAPEPGPVVEAVEEAQPAEPDPNEITAPPEKPRRGWWRR