Protein Info for CCNA_01925 in Caulobacter crescentus NA1000

Annotation: coniferyl aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to CALB_CAUVC: Probable coniferyl aldehyde dehydrogenase (calB) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00154, coniferyl-aldehyde dehydrogenase [EC: 1.2.1.68] (inferred from 100% identity to ccr:CC_1849)

Predicted SEED Role

No annotation

MetaCyc Pathways

ferulate and sinapate biosynthesis (1/4 steps found)

KEGG Metabolic Maps

Phenylpropanoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.68

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9G0 at UniProt or InterPro

Protein Sequence (485 amino acids)

>CCNA_01925 coniferyl aldehyde dehydrogenase (Caulobacter crescentus NA1000)
MNAPVNLSSDAHKAVMNDVLQRQKAAHLRDGPPSAEKRIQWLNRCIDLLVGHQAEIAKAV
NQDFGSRSPEATSLTDVAGSIGPLKHAREHLTKWMKPEKHKTTPAILGLFGAKATVQWQP
KGVVGVISPWNFPVNLTFAPLAGVFAAGNRAMIKPSEFTPATSDLLKAMFAKAFNEEEVA
VFVGGPEVGQAFSGLAFDHLVFTGATSVAKHVMRAAAENLVPVTLELGGKSPVILSRGAD
MATAAARVMNGKTLNAGQICLAPDYVLAPQEDVEAFVKEAQAAVSRYFPTIKDNPDYTAV
VAQRHYDRVKGYVDDARAKGARVIEINPAGEDLSQQEHRKIPPTLILDPTDDMKVMQEEI
FGPVLPVKGYKTVDEAVDYVNAHDRPLALYWFGTDEAEKDRVLERTTSGGVTVNDVIFHV
AQENLPFGGIGPAGMGAYHGYDGFREFSHRKAVFQQLKKDIAPMLGLRPPYGEGIRKYLA
GQIKK