Protein Info for CCNA_01826 in Caulobacter crescentus NA1000

Annotation: vitamin B12 receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF07715: Plug" amino acids 56 to 163 (108 residues), 85.7 bits, see alignment E=4.7e-28 PF00593: TonB_dep_Rec" amino acids 228 to 623 (396 residues), 190.5 bits, see alignment E=1.6e-59 PF14905: OMP_b-brl_3" amino acids 440 to 631 (192 residues), 33 bits, see alignment E=5.6e-12

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to ccs:CCNA_01826)

Predicted SEED Role

"Outer membrane vitamin B12 receptor BtuB" in subsystem Coenzyme B12 biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7I0 at UniProt or InterPro

Protein Sequence (650 amino acids)

>CCNA_01826 vitamin B12 receptor (Caulobacter crescentus NA1000)
MIRALLSSTALATALLAAPALADDQKAPEADVAGATGANGVAELVVTATRTVQPIEKVGA
AVTVLTQPAIEASQAISVTELLAQTPSVTFARNGGVGTATSLYIRGAESHHTVVLIDGVK
LNDPSSIQGGFNSGNLLVGDISRIEVLRGAQSTLWGSQAVGGVVNIVTAEPTTPFTSSLS
AEAGARKTGYLRGAVGGASDKVTWRVAGGYYTTDGFSAHKTGKEADGYQNAGASGRLRVK
LTDAVSVETRAVYSRGKNDFDGFNTDSPEFGRTKELVIYQGLNAALLDGRWNNRVGFAYT
DTDRENYNPARAAVPMTFDAAGKNKRWEYQGVFAITETWTATFGAESERSRMRTRSPSVA
NPNVAFRTGKTSADSLYGQLQAEIAPGLTVTGGLRYEDHDAYGAHTLGQVGAAWALNDNA
TVLRAGYSQGFRAPGLYELFSEYGNPALSPEEFDSWEAGVEQRFLEGKVRASATVFHREA
DNEIRFFSCSFGATDTICAPGGVFRFGYYRNLQKTKAQGLELIAEARPVEGLTITGNYTY
TEAELAAGANTGKQLSRRPKDLANLSATYRWPVGLSTTVAVRYVGKTYNNEANTVAVSDY
ATVDLRASYPISETLEVYGRVENALDKDYQTILNYGTPGRGAFLGLRARF