Protein Info for CCNA_01782 in Caulobacter crescentus NA1000

Annotation: polyphosphate kinase 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 738 TIGR03705: polyphosphate kinase 1" amino acids 32 to 712 (681 residues), 930.6 bits, see alignment E=2.8e-284 PF13089: PP_kinase_N" amino acids 33 to 137 (105 residues), 127.3 bits, see alignment E=7.4e-41 PF02503: PP_kinase" amino acids 149 to 328 (180 residues), 177.3 bits, see alignment E=6.4e-56 PF17941: PP_kinase_C_1" amino acids 357 to 521 (165 residues), 251.1 bits, see alignment E=1e-78 PF13090: PP_kinase_C" amino acids 528 to 696 (169 residues), 201 bits, see alignment E=2.6e-63

Best Hits

Swiss-Prot: 62% identical to PPK1_RHOPT: Polyphosphate kinase (ppk) from Rhodopseudomonas palustris (strain TIE-1)

KEGG orthology group: K00937, polyphosphate kinase [EC: 2.7.4.1] (inferred from 100% identity to ccr:CC_1710)

Predicted SEED Role

"Polyphosphate kinase (EC 2.7.4.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism or Purine conversions (EC 2.7.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.1

Use Curated BLAST to search for 2.7.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7E3 at UniProt or InterPro

Protein Sequence (738 amino acids)

>CCNA_01782 polyphosphate kinase 1 (Caulobacter crescentus NA1000)
MTDALPIAANAPVAANASALTLDVELMASPERFFNRELSWLAFNQRVLEESSNPRHPLLE
RLRFLSISANNLDEFYMVRVAGLKGQVREGVRVISQDGLIPSEQLTRINASAAELMAEQQ
KIWRLLRTQLWDEGLKLLDAKDIEGDDKVRAEEIFRNQIFPVMTPLAIDPAHPFPFIPNL
GFCLALKLRRIADDKHLYALAPIPSQVRRFWELSSVVSRGRKRQRKIVALESLIILFLEH
LFPGYEVEGLGLFRLIRDSDLEIEEEAEDLVREFEARLKKRRLGQVVRVKIQTTMPADLR
DFIVEGLRAEPEDVVLLDGKLGLAQMSELIPPDRPDLKFPPFNARFPERIRDHGGDCFAA
IREKDILVHHPFESFDVVVQFLRQAARDPNVLAIKQTLYRTSKDSPIVAALIEAADNGKN
VTALVEIKARFDEENNLKWARDLERAGVHVVFGFVDWKTHAKLSVVVRREGEALRTYCHY
GTGNYHPQTARVYTDLSLFTCDPALGRDGGKLFNFITGYAQPGRLEKLSFSPQTLKPDLL
RMIALEADAAREGRPAGIWAKMNAVVDPQIIDALYKASQAGVQIDLVVRGICCLRPGIKG
LSENIRVKSIVGRFLEHSRIVAFANGAPMPSAQTRLYMSSADWMPRNLDRRVESLVPIEN
PTVHQQVLDQIMVANLNDEAQSWKLGSEGDYARDPAWKTKGAFSAHDYFMTNPSLSGRGH
GARDLPRAFDHVGPKRKR