Protein Info for CCNA_01763 in Caulobacter crescentus NA1000

Annotation: multifunctional aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 493 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF02789: Peptidase_M17_N" amino acids 20 to 139 (120 residues), 90 bits, see alignment E=1.2e-29 PF00883: Peptidase_M17" amino acids 177 to 483 (307 residues), 415.8 bits, see alignment E=1.2e-128

Best Hits

Swiss-Prot: 100% identical to AMPA_CAUVC: Probable cytosol aminopeptidase (pepA) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to ccr:CC_1692)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8R6 at UniProt or InterPro

Protein Sequence (493 amino acids)

>CCNA_01763 multifunctional aminopeptidase (Caulobacter crescentus NA1000)
MRIEFVPVDTQAGATAALAVLAHEGAALSPEARAANEATGGALARAIAGGRFTGAKGQTL
DIVAPNGLEAARVVLVGVDGSGAVEPEAVELAAASAFQAVKTSGVVELVLKLGADAETAA
RAAFGARLAAYRFDKYRTTEKAEKKPSVQVVKIAAADPVKAQKAYEPLAALADAIVFSRN
LVSEPANILHPEEFAARAKGLESLGLEVEILGEAEMAKLGMGSLLGVGQGSVRESQLVIM
KWMGAADKSAQPIAFVGKGVCFDTGGISIKPADGMEDMKWDMGGAAAVAGVMHALAGRKA
KVNAIGVLGLVENMPDGNAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQERFKP
QFMIDLATLTGAIIISLGHDYAGLFSNNDGLSEKLLAAGKAERESLWRLPLPAAYEKQIE
SPIADMKNIGGRPAGSITAGLFLQKFVNGVPWAHLDIASVAWKKPSADPTVPDGAVGYGV
RLLNRLVADAYEG