Protein Info for CCNA_01758 in Caulobacter crescentus NA1000

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 333 TIGR00557: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA" amino acids 5 to 328 (324 residues), 399.9 bits, see alignment E=4.8e-124 PF04166: PdxA" amino acids 34 to 324 (291 residues), 344.1 bits, see alignment E=3.4e-107

Best Hits

Swiss-Prot: 100% identical to PDXA_CAUVC: 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 100% identity to ccs:CCNA_01758)

Predicted SEED Role

"4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.262)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.262

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8R1 at UniProt or InterPro

Protein Sequence (333 amino acids)

>CCNA_01758 4-hydroxythreonine-4-phosphate dehydrogenase (Caulobacter crescentus NA1000)
MTSRPLAISAGDPAGVGAEIIAKAWRALRQDGPTFVVIGDAQLLASAGGGVKVRAVTRPQ
EAAQVFPDALPVLDIPVLSPVVYGRPSPSHAPQIIRWIETGVGLALSGAVSGLVTAPIAK
APLYEAGFQFPGHTEFLAELTAAASMVGARGPVMMLAAGDLRATLVTIHTALAKAPSALT
TEAIINSGLVTAQALRKDFGIAEPRLAVAALNPHAGEGGALGREEIDIIAPAVEALRALG
VQASGPAPADTLFHPEARARYDGVLCMYHDQALIPVKMLDFWGGVNITLGLPIVRTSPDH
GTGFDIAGRGIARPDSLIAAIQLAAKIAARRGV